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| Main Authors: | , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2512.07307 |
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| _version_ | 1866911307152752640 |
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| author | Zhao, Zhiyuan Shi, Qian Xu, Shaoyi Ye, Xiangyu Shen, Mengze Su, Jia Wang, Ya Xie, Tianyu Hu, Qingsong Shi, Fazhan Du, Jiangfeng |
| author_facet | Zhao, Zhiyuan Shi, Qian Xu, Shaoyi Ye, Xiangyu Shen, Mengze Su, Jia Wang, Ya Xie, Tianyu Hu, Qingsong Shi, Fazhan Du, Jiangfeng |
| contents | Identification of individual cells within heterogeneous populations is essential for biomedical research and clinical diagnostics. Conventional labeling-based sorting methods, such as fluorescence-activated cell sorting and magnetic-activated cell sorting, enable precise sorting when reliable markers are available. However, their applicability is limited in cells lacking defined markers or sensitive to labeling, as labeling can compromise cellular viability and function. We present a single-cell identification approach using quantum-enhanced NMR with diamond nitrogen-vacancy centers for label-free detection of intracellular proton ($^1$H) signals. Using this method, we distinguish two human tumor cell lines by their proton spin-lattice ($T_1$) relaxation times, which serve as a cell-intrinsic physicochemical signature. It lays the groundwork for label-free sorting applications in rare cell analysis, personalized medicine, and single-cell diagnostics. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_07307 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Single-cell identification with quantum-enhanced nuclear magnetic resonance Zhao, Zhiyuan Shi, Qian Xu, Shaoyi Ye, Xiangyu Shen, Mengze Su, Jia Wang, Ya Xie, Tianyu Hu, Qingsong Shi, Fazhan Du, Jiangfeng Quantum Physics Biological Physics Medical Physics Identification of individual cells within heterogeneous populations is essential for biomedical research and clinical diagnostics. Conventional labeling-based sorting methods, such as fluorescence-activated cell sorting and magnetic-activated cell sorting, enable precise sorting when reliable markers are available. However, their applicability is limited in cells lacking defined markers or sensitive to labeling, as labeling can compromise cellular viability and function. We present a single-cell identification approach using quantum-enhanced NMR with diamond nitrogen-vacancy centers for label-free detection of intracellular proton ($^1$H) signals. Using this method, we distinguish two human tumor cell lines by their proton spin-lattice ($T_1$) relaxation times, which serve as a cell-intrinsic physicochemical signature. It lays the groundwork for label-free sorting applications in rare cell analysis, personalized medicine, and single-cell diagnostics. |
| title | Single-cell identification with quantum-enhanced nuclear magnetic resonance |
| topic | Quantum Physics Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2512.07307 |