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| Main Authors: | , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2512.08929 |
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| _version_ | 1866911315969179648 |
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| author | Pan, Guanjun Yin, Hong-Ming |
| author_facet | Pan, Guanjun Yin, Hong-Ming |
| contents | In this paper, we study a well-posedness problem on a new mathematical model for cancer invasion within the plasminogen activation system, which explicitly incorporates cooperation with host normal cells. Key biological mechanisms--including chemotaxis, haptotaxis, recruitment, logistic growth, and natural degradation of normal cells--along with other primary components (cancer cells, vitronectin, uPA, uPAI-1 and plasmin) are modeled via a continuum framework of cancer cell invasion of the extracellular matrix. The resulting model constitutes a strongly coupled, cross-diffusion hybrid system of differential equations. The primary mathematical challenges arise from the strongly coupled cross-diffusion terms, the parabolic operators of divergence form, and the interaction between the cross-diffusion fluxes and the ODE components. We address these by deriving several a priori estimates for dimensions d less or equal to 3. Subsequently, we employ a decoupling strategy to split the system into proper sub-problems, establishing the existence (and uniqueness) for each subsystem. Finally, we demonstrate the global existence and uniqueness of the solution for dimensions d less or equal to 2 and the global existence of a solution for dimension d = 3. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_08929 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | On a cross-diffusion hybrid model: Cancer Invasion Tissue with Normal Cell Involved Pan, Guanjun Yin, Hong-Ming Analysis of PDEs In this paper, we study a well-posedness problem on a new mathematical model for cancer invasion within the plasminogen activation system, which explicitly incorporates cooperation with host normal cells. Key biological mechanisms--including chemotaxis, haptotaxis, recruitment, logistic growth, and natural degradation of normal cells--along with other primary components (cancer cells, vitronectin, uPA, uPAI-1 and plasmin) are modeled via a continuum framework of cancer cell invasion of the extracellular matrix. The resulting model constitutes a strongly coupled, cross-diffusion hybrid system of differential equations. The primary mathematical challenges arise from the strongly coupled cross-diffusion terms, the parabolic operators of divergence form, and the interaction between the cross-diffusion fluxes and the ODE components. We address these by deriving several a priori estimates for dimensions d less or equal to 3. Subsequently, we employ a decoupling strategy to split the system into proper sub-problems, establishing the existence (and uniqueness) for each subsystem. Finally, we demonstrate the global existence and uniqueness of the solution for dimensions d less or equal to 2 and the global existence of a solution for dimension d = 3. |
| title | On a cross-diffusion hybrid model: Cancer Invasion Tissue with Normal Cell Involved |
| topic | Analysis of PDEs |
| url | https://arxiv.org/abs/2512.08929 |