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Main Authors: Mao, Kangkun, Xu, Fang, Ding, Jinru, Jiang, Yidong, Yao, Yujun, Chen, Yirong, Liu, Junming, Wu, Xiaoqin, Wu, Qian, Huang, Xiaoyan, Xu, Jie
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2512.10313
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author Mao, Kangkun
Xu, Fang
Ding, Jinru
Jiang, Yidong
Yao, Yujun
Chen, Yirong
Liu, Junming
Wu, Xiaoqin
Wu, Qian
Huang, Xiaoyan
Xu, Jie
author_facet Mao, Kangkun
Xu, Fang
Ding, Jinru
Jiang, Yidong
Yao, Yujun
Chen, Yirong
Liu, Junming
Wu, Xiaoqin
Wu, Qian
Huang, Xiaoyan
Xu, Jie
contents Epidemic response planning is essential yet traditionally reliant on labor-intensive manual methods. This study aimed to design and evaluate EpiPlanAgent, an agent-based system using large language models (LLMs) to automate the generation and validation of digital emergency response plans. The multi-agent framework integrated task decomposition, knowledge grounding, and simulation modules. Public health professionals tested the system using real-world outbreak scenarios in a controlled evaluation. Results demonstrated that EpiPlanAgent significantly improved the completeness and guideline alignment of plans while drastically reducing development time compared to manual workflows. Expert evaluation confirmed high consistency between AI-generated and human-authored content. User feedback indicated strong perceived utility. In conclusion, EpiPlanAgent provides an effective, scalable solution for intelligent epidemic response planning, demonstrating the potential of agentic AI to transform public health preparedness.
format Preprint
id arxiv_https___arxiv_org_abs_2512_10313
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle EpiPlanAgent: Agentic Automated Epidemic Response Planning
Mao, Kangkun
Xu, Fang
Ding, Jinru
Jiang, Yidong
Yao, Yujun
Chen, Yirong
Liu, Junming
Wu, Xiaoqin
Wu, Qian
Huang, Xiaoyan
Xu, Jie
Artificial Intelligence
Computers and Society
Epidemic response planning is essential yet traditionally reliant on labor-intensive manual methods. This study aimed to design and evaluate EpiPlanAgent, an agent-based system using large language models (LLMs) to automate the generation and validation of digital emergency response plans. The multi-agent framework integrated task decomposition, knowledge grounding, and simulation modules. Public health professionals tested the system using real-world outbreak scenarios in a controlled evaluation. Results demonstrated that EpiPlanAgent significantly improved the completeness and guideline alignment of plans while drastically reducing development time compared to manual workflows. Expert evaluation confirmed high consistency between AI-generated and human-authored content. User feedback indicated strong perceived utility. In conclusion, EpiPlanAgent provides an effective, scalable solution for intelligent epidemic response planning, demonstrating the potential of agentic AI to transform public health preparedness.
title EpiPlanAgent: Agentic Automated Epidemic Response Planning
topic Artificial Intelligence
Computers and Society
url https://arxiv.org/abs/2512.10313