Prevalence of Upper Extremity Distal Predominant Weakness Pattern in Chronic Stroke
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arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| _version_ | 1866915673097109504 |
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| author | Baxter, Ryan H. Tsutsumi, Kotaro Slutzky, Marc W. Do, An H. |
| author_facet | Baxter, Ryan H. Tsutsumi, Kotaro Slutzky, Marc W. Do, An H. |
| contents | Background: Hemiparesis after subcortical stroke is classically described as distal upper-extremity (UE) predominant, but prevalence data in chronic stroke is limited. Objective: Determine the prevalence of distal predominant UE weakness in exclusively subcortical chronic stroke versus other stroke distributions, characterize cohort differences, and describe UE weakness patterns in chronic stroke overall. Methods: Outpatient records were retrospectively reviewed to identify chronic stroke subjects. Lesion locations were classified from radiographic reports as exclusively subcortical or not (using a whole brain and supratentorial definition). UE weakness was categorized as distal predominant or not. Prevalence was compared with $χ$-squared testing and odds ratios (OR). Results: 250 subjects were included (mean 861 days post-stroke). Using the whole-brain definition, distal predominant weakness occurred in 30.6% of exclusively subcortical versus 17.4% of non-exclusively subcortical strokes (OR 2.09, 95% CI 1.15-3.81; p=0.014). Using the supratentorial definition, distal predominant weakness occurred in 27.9% versus 17.9%, respectively (OR 2.16, 95% CI 1.17-3.96; p=0.012). Across all chronic strokes, 60% had no UE weakness; distal predominant weakness was the most common weakness pattern (23%), followed by uniform UE weakness (12%); proximal predominant weakness was rare (3%). Conclusions: Distal predominant UE weakness is more prevalent in chronic exclusively subcortical stroke than in non-subcortical stroke. These prevalence estimates may help predict long-term outcomes based on lesion location, support rehabilitation planning, and aid clinical lesion localization and research prioritization. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_12147 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Prevalence of Upper Extremity Distal Predominant Weakness Pattern in Chronic Stroke Baxter, Ryan H. Tsutsumi, Kotaro Slutzky, Marc W. Do, An H. Other Quantitative Biology Background: Hemiparesis after subcortical stroke is classically described as distal upper-extremity (UE) predominant, but prevalence data in chronic stroke is limited. Objective: Determine the prevalence of distal predominant UE weakness in exclusively subcortical chronic stroke versus other stroke distributions, characterize cohort differences, and describe UE weakness patterns in chronic stroke overall. Methods: Outpatient records were retrospectively reviewed to identify chronic stroke subjects. Lesion locations were classified from radiographic reports as exclusively subcortical or not (using a whole brain and supratentorial definition). UE weakness was categorized as distal predominant or not. Prevalence was compared with $χ$-squared testing and odds ratios (OR). Results: 250 subjects were included (mean 861 days post-stroke). Using the whole-brain definition, distal predominant weakness occurred in 30.6% of exclusively subcortical versus 17.4% of non-exclusively subcortical strokes (OR 2.09, 95% CI 1.15-3.81; p=0.014). Using the supratentorial definition, distal predominant weakness occurred in 27.9% versus 17.9%, respectively (OR 2.16, 95% CI 1.17-3.96; p=0.012). Across all chronic strokes, 60% had no UE weakness; distal predominant weakness was the most common weakness pattern (23%), followed by uniform UE weakness (12%); proximal predominant weakness was rare (3%). Conclusions: Distal predominant UE weakness is more prevalent in chronic exclusively subcortical stroke than in non-subcortical stroke. These prevalence estimates may help predict long-term outcomes based on lesion location, support rehabilitation planning, and aid clinical lesion localization and research prioritization. |
| title | Prevalence of Upper Extremity Distal Predominant Weakness Pattern in Chronic Stroke |
| topic | Other Quantitative Biology |
| url | https://arxiv.org/abs/2512.12147 |