Transmembrane transport of polymer brush-grafted nanoparticles into giant vesicles
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arXiv
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| Main Authors: | , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866908711683883008 |
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| author | He, Shuai Pan, Junxing Zhang, Jinjun |
| author_facet | He, Shuai Pan, Junxing Zhang, Jinjun |
| contents | Polymer brush-grafted nanoparticles have significant application value in fields such as gene therapy and targeted drug delivery. A profound understanding of the interaction mechanisms between these particles and cell membranes represents a critical scientific challenge in biophysics. Using the Self-Consistent Field Theory, this work systematically explores the transmembrane transport of polymer brush-grafted nanoparticles into giant vesicles. The impacts of critical parameters-polymer brush grafting density, nanoparticle size, and giant vesicle membrane thickness-on transport behavior are comprehensively elucidated. The findings reveal two distinct transmembrane transport mechanisms for polymer brush-grafted nanoparticles, which are governed by membrane thickness and grafting density. At high grafting density, the nanoparticles undergo direct transmembrane translocation; at low grafting density, transport occurs via endocytosis. Thermodynamic analysis identifies entropy as the dominant driving force for this process. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_12908 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Transmembrane transport of polymer brush-grafted nanoparticles into giant vesicles He, Shuai Pan, Junxing Zhang, Jinjun Soft Condensed Matter Biological Physics Polymer brush-grafted nanoparticles have significant application value in fields such as gene therapy and targeted drug delivery. A profound understanding of the interaction mechanisms between these particles and cell membranes represents a critical scientific challenge in biophysics. Using the Self-Consistent Field Theory, this work systematically explores the transmembrane transport of polymer brush-grafted nanoparticles into giant vesicles. The impacts of critical parameters-polymer brush grafting density, nanoparticle size, and giant vesicle membrane thickness-on transport behavior are comprehensively elucidated. The findings reveal two distinct transmembrane transport mechanisms for polymer brush-grafted nanoparticles, which are governed by membrane thickness and grafting density. At high grafting density, the nanoparticles undergo direct transmembrane translocation; at low grafting density, transport occurs via endocytosis. Thermodynamic analysis identifies entropy as the dominant driving force for this process. |
| title | Transmembrane transport of polymer brush-grafted nanoparticles into giant vesicles |
| topic | Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2512.12908 |