Fast label-free point-scanning super-resolution imaging for endoscopy
Fuente:
arXiv
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866915676099182592 |
|---|---|
| author | Xu, Ning Williams, Calum Spicer, Graham Wang, Qixia Tan, Qiaofeng Bohndiek, Sarah E. |
| author_facet | Xu, Ning Williams, Calum Spicer, Graham Wang, Qixia Tan, Qiaofeng Bohndiek, Sarah E. |
| contents | Optical endoscopy plays a crucial role in minimally invasive medical diagnostics and therapeutic procedures. Nonetheless, state-of-the-art endoscopic zoom objectives are bulky, requiring multi-element lens actuation, which can limit continued miniaturization. Point-scanning super-resolution approaches improve spatial resolution by illuminating the scene with a reduced-width focused spot, yet mechanical scanning requirements limit applicability in clinical settings. Here, we experimentally demonstrate a Fast label-free point-scanning super-resolution (Flaps) microscopy system, which exploits a multi-level phase-only diffractive optical element (DOE) to generate super-resolution spot(s) and uses a high-speed digital micromirror device (DMD) to deliver the illumination without mechanical scanning. Two imaging architectures are explored: a single super-resolution spot (0.47 Airy spot) or a 5 times 5 super-resolution spot array (0.52 Airy spot) in the far-field; the DMD scans the spot or spot array in the object plane at kHz rates. To demonstrate super-resolution imaging with high-speed acquisition using optical elements suitable for future deployment in endoscopy, we image a label-free resolution test target and fluorescently labelled cells. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_13432 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Fast label-free point-scanning super-resolution imaging for endoscopy Xu, Ning Williams, Calum Spicer, Graham Wang, Qixia Tan, Qiaofeng Bohndiek, Sarah E. Optics Instrumentation and Detectors Medical Physics Optical endoscopy plays a crucial role in minimally invasive medical diagnostics and therapeutic procedures. Nonetheless, state-of-the-art endoscopic zoom objectives are bulky, requiring multi-element lens actuation, which can limit continued miniaturization. Point-scanning super-resolution approaches improve spatial resolution by illuminating the scene with a reduced-width focused spot, yet mechanical scanning requirements limit applicability in clinical settings. Here, we experimentally demonstrate a Fast label-free point-scanning super-resolution (Flaps) microscopy system, which exploits a multi-level phase-only diffractive optical element (DOE) to generate super-resolution spot(s) and uses a high-speed digital micromirror device (DMD) to deliver the illumination without mechanical scanning. Two imaging architectures are explored: a single super-resolution spot (0.47 Airy spot) or a 5 times 5 super-resolution spot array (0.52 Airy spot) in the far-field; the DMD scans the spot or spot array in the object plane at kHz rates. To demonstrate super-resolution imaging with high-speed acquisition using optical elements suitable for future deployment in endoscopy, we image a label-free resolution test target and fluorescently labelled cells. |
| title | Fast label-free point-scanning super-resolution imaging for endoscopy |
| topic | Optics Instrumentation and Detectors Medical Physics |
| url | https://arxiv.org/abs/2512.13432 |