Quantitative phase nano-imaging with a laboratory source
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866915686332235776 |
|---|---|
| author | Fardin, Luca Armstrong, Chris Astolfo, Alberto Binet, Sebastian Ignacio Allen Boone, Matthieu N. Fitzgarrald, Rebecca Ma, Yong Thomas, Alexander Batey, Darren J. Olivo, Alessandro Cipiccia, Silvia |
| author_facet | Fardin, Luca Armstrong, Chris Astolfo, Alberto Binet, Sebastian Ignacio Allen Boone, Matthieu N. Fitzgarrald, Rebecca Ma, Yong Thomas, Alexander Batey, Darren J. Olivo, Alessandro Cipiccia, Silvia |
| contents | Investigating the structure of matter at the nanoscale non destructively is a key capability enabled by X-ray imaging. One of the most powerful nano-imaging methods is X-ray ptychography, a coherent diffraction imaging technique that has become the go-to method at synchrotron facilities for applications ranging from brain imaging to battery materials. However, the requirements in terms of X-ray beam quality have limited its use to large synchrotron facilities and, to date, only one attempt has been made to translate the technique to a small-scale laboratory. To unleash the power of this technique to the broad user community of laboratory X-ray sources, there are outstanding questions to answer including whether the quantitativeness of the information is preserved in a laboratory despite the drastic decrease in X-ray flux of several orders of magnitude, with respect to synchrotron instruments. In this study not only we demonstrate that the quantitativeness of X-ray ptychography is preserved in a laboratory setting, but we also apply the method to the imaging of a brain tissue phantom. Finally, we describe the current challenges and limitations, and we set the basis for further development and future directions of quantitative nano-imaging with laboratory X-ray sources. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_17357 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Quantitative phase nano-imaging with a laboratory source Fardin, Luca Armstrong, Chris Astolfo, Alberto Binet, Sebastian Ignacio Allen Boone, Matthieu N. Fitzgarrald, Rebecca Ma, Yong Thomas, Alexander Batey, Darren J. Olivo, Alessandro Cipiccia, Silvia Computational Physics Instrumentation and Detectors Optics Investigating the structure of matter at the nanoscale non destructively is a key capability enabled by X-ray imaging. One of the most powerful nano-imaging methods is X-ray ptychography, a coherent diffraction imaging technique that has become the go-to method at synchrotron facilities for applications ranging from brain imaging to battery materials. However, the requirements in terms of X-ray beam quality have limited its use to large synchrotron facilities and, to date, only one attempt has been made to translate the technique to a small-scale laboratory. To unleash the power of this technique to the broad user community of laboratory X-ray sources, there are outstanding questions to answer including whether the quantitativeness of the information is preserved in a laboratory despite the drastic decrease in X-ray flux of several orders of magnitude, with respect to synchrotron instruments. In this study not only we demonstrate that the quantitativeness of X-ray ptychography is preserved in a laboratory setting, but we also apply the method to the imaging of a brain tissue phantom. Finally, we describe the current challenges and limitations, and we set the basis for further development and future directions of quantitative nano-imaging with laboratory X-ray sources. |
| title | Quantitative phase nano-imaging with a laboratory source |
| topic | Computational Physics Instrumentation and Detectors Optics |
| url | https://arxiv.org/abs/2512.17357 |