SkinGenBench: Generative Model and Preprocessing Effects for Synthetic Dermoscopic Augmentation in Melanoma Diagnosis

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Main Authors: Pritam, N. A. Adarsh, O, Jeba Shiney, Jain, Sanyam
Format: Preprint
Published: 2025
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author Pritam, N. A. Adarsh
O, Jeba Shiney
Jain, Sanyam
author_facet Pritam, N. A. Adarsh
O, Jeba Shiney
Jain, Sanyam
contents This work introduces SkinGenBench, a systematic biomedical imaging benchmark that investigates how preprocessing complexity interacts with generative model choice for synthetic dermoscopic image augmentation and downstream melanoma diagnosis. Using a curated dataset of $14,116$ dermoscopic images from HAM10000 and MILK10K across five lesion classes, we evaluate the two representative generative paradigms: StyleGAN2-ADA and Denoising Diffusion Probabilistic Models (DDPMs) under basic geometric augmentation and advanced artifact removal pipelines. Synthetic melanoma images are assessed using established perceptual and distributional metrics (FID, KID, IS), feature space analysis, and their impact on diagnostic performance across five downstream classifiers. Experimental results demonstrate that generative architecture choice has a stronger influence on both image fidelity and diagnostic utility than preprocessing complexity. StyleGAN2-ADA consistently produced synthetic images more closely aligned with real data distributions, achieving the lowest FID ($\approx 65.5$) and KID ($\approx 0.05$), while diffusion models generated higher variance samples at the cost of reduced perceptual fidelity and class anchoring. Advanced artifact removal yielded only marginal improvements in generative metrics and provided limited downstream diagnostic gains, suggesting possible suppression of clinically relevant texture cues. In contrast, synthetic data augmentation substantially improved melanoma detection with $8$-$15$\% absolute gains in melanoma F1-score, and ViT-B/16 achieving F1 $\approx 0.88$ and ROC-AUC $\approx 0.98$, representing an improvement of approximately $14\%$ over non-augmented baselines. Our code can be found at https://github.com/adarsh-crafts/SkinGenBench
format Preprint
id arxiv_https___arxiv_org_abs_2512_17585
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle SkinGenBench: Generative Model and Preprocessing Effects for Synthetic Dermoscopic Augmentation in Melanoma Diagnosis
Pritam, N. A. Adarsh
O, Jeba Shiney
Jain, Sanyam
Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
This work introduces SkinGenBench, a systematic biomedical imaging benchmark that investigates how preprocessing complexity interacts with generative model choice for synthetic dermoscopic image augmentation and downstream melanoma diagnosis. Using a curated dataset of $14,116$ dermoscopic images from HAM10000 and MILK10K across five lesion classes, we evaluate the two representative generative paradigms: StyleGAN2-ADA and Denoising Diffusion Probabilistic Models (DDPMs) under basic geometric augmentation and advanced artifact removal pipelines. Synthetic melanoma images are assessed using established perceptual and distributional metrics (FID, KID, IS), feature space analysis, and their impact on diagnostic performance across five downstream classifiers. Experimental results demonstrate that generative architecture choice has a stronger influence on both image fidelity and diagnostic utility than preprocessing complexity. StyleGAN2-ADA consistently produced synthetic images more closely aligned with real data distributions, achieving the lowest FID ($\approx 65.5$) and KID ($\approx 0.05$), while diffusion models generated higher variance samples at the cost of reduced perceptual fidelity and class anchoring. Advanced artifact removal yielded only marginal improvements in generative metrics and provided limited downstream diagnostic gains, suggesting possible suppression of clinically relevant texture cues. In contrast, synthetic data augmentation substantially improved melanoma detection with $8$-$15$\% absolute gains in melanoma F1-score, and ViT-B/16 achieving F1 $\approx 0.88$ and ROC-AUC $\approx 0.98$, representing an improvement of approximately $14\%$ over non-augmented baselines. Our code can be found at https://github.com/adarsh-crafts/SkinGenBench
title SkinGenBench: Generative Model and Preprocessing Effects for Synthetic Dermoscopic Augmentation in Melanoma Diagnosis
topic Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2512.17585