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Main Authors: Xia, Zeyu, Ma, Jinzhe, Zheng, Congjie, Zhang, Shufei, Li, Yuqiang, Su, Hang, Hu, P., Zhang, Changshui, Gong, Xingao, Ouyang, Wanli, Bai, Lei, Zhou, Dongzhan, Su, Mao
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2512.19458
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author Xia, Zeyu
Ma, Jinzhe
Zheng, Congjie
Zhang, Shufei
Li, Yuqiang
Su, Hang
Hu, P.
Zhang, Changshui
Gong, Xingao
Ouyang, Wanli
Bai, Lei
Zhou, Dongzhan
Su, Mao
author_facet Xia, Zeyu
Ma, Jinzhe
Zheng, Congjie
Zhang, Shufei
Li, Yuqiang
Su, Hang
Hu, P.
Zhang, Changshui
Gong, Xingao
Ouyang, Wanli
Bai, Lei
Zhou, Dongzhan
Su, Mao
contents Large Language Models (LLMs) have emerged as powerful tools for accelerating scientific discovery, yet their static knowledge and hallucination issues hinder autonomous research applications. Recent advances integrate LLMs into agentic frameworks, enabling retrieval, reasoning, and tool use for complex scientific workflows. Here, we present a domain-specialized agent designed for reliable automation of first-principles materials computations. By embedding domain expertise, the agent ensures physically coherent multi-step workflows and consistently selects convergent, well-posed parameters, thereby enabling reliable end-to-end computational execution. A new benchmark of diverse computational tasks demonstrates that our system significantly outperforms standalone LLMs in both accuracy and robustness. This work establishes a verifiable foundation for autonomous computational experimentation and represents a key step toward fully automated scientific discovery.
format Preprint
id arxiv_https___arxiv_org_abs_2512_19458
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle An Agentic Framework for Autonomous Materials Computation
Xia, Zeyu
Ma, Jinzhe
Zheng, Congjie
Zhang, Shufei
Li, Yuqiang
Su, Hang
Hu, P.
Zhang, Changshui
Gong, Xingao
Ouyang, Wanli
Bai, Lei
Zhou, Dongzhan
Su, Mao
Artificial Intelligence
Materials Science
Large Language Models (LLMs) have emerged as powerful tools for accelerating scientific discovery, yet their static knowledge and hallucination issues hinder autonomous research applications. Recent advances integrate LLMs into agentic frameworks, enabling retrieval, reasoning, and tool use for complex scientific workflows. Here, we present a domain-specialized agent designed for reliable automation of first-principles materials computations. By embedding domain expertise, the agent ensures physically coherent multi-step workflows and consistently selects convergent, well-posed parameters, thereby enabling reliable end-to-end computational execution. A new benchmark of diverse computational tasks demonstrates that our system significantly outperforms standalone LLMs in both accuracy and robustness. This work establishes a verifiable foundation for autonomous computational experimentation and represents a key step toward fully automated scientific discovery.
title An Agentic Framework for Autonomous Materials Computation
topic Artificial Intelligence
Materials Science
url https://arxiv.org/abs/2512.19458