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Main Authors: Darges, John E., Afkham, Babak Maboudi, Chung, Matthias
Format: Preprint
Published: 2025
Subjects:
Online Access:https://arxiv.org/abs/2512.23763
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author Darges, John E.
Afkham, Babak Maboudi
Chung, Matthias
author_facet Darges, John E.
Afkham, Babak Maboudi
Chung, Matthias
contents We introduce Neural Optimal Design of Experiments, a learning-based framework for optimal experimental design in inverse problems that avoids classical bilevel optimization and indirect sparsity regularization. NODE jointly trains a neural reconstruction model and a fixed-budget set of continuous design variables representing sensor locations, sampling times, or measurement angles, within a single optimization loop. By optimizing measurement locations directly rather than weighting a dense grid of candidates, the proposed approach enforces sparsity by design, eliminates the need for l1 tuning, and substantially reduces computational complexity. We validate NODE on an analytically tractable exponential growth benchmark, on MNIST image sampling, and illustrate its effectiveness on a real world sparse view X ray CT example. In all cases, NODE outperforms baseline approaches, demonstrating improved reconstruction accuracy and task-specific performance.
format Preprint
id arxiv_https___arxiv_org_abs_2512_23763
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Neural Optimal Design of Experiment for Inverse Problems
Darges, John E.
Afkham, Babak Maboudi
Chung, Matthias
Machine Learning
We introduce Neural Optimal Design of Experiments, a learning-based framework for optimal experimental design in inverse problems that avoids classical bilevel optimization and indirect sparsity regularization. NODE jointly trains a neural reconstruction model and a fixed-budget set of continuous design variables representing sensor locations, sampling times, or measurement angles, within a single optimization loop. By optimizing measurement locations directly rather than weighting a dense grid of candidates, the proposed approach enforces sparsity by design, eliminates the need for l1 tuning, and substantially reduces computational complexity. We validate NODE on an analytically tractable exponential growth benchmark, on MNIST image sampling, and illustrate its effectiveness on a real world sparse view X ray CT example. In all cases, NODE outperforms baseline approaches, demonstrating improved reconstruction accuracy and task-specific performance.
title Neural Optimal Design of Experiment for Inverse Problems
topic Machine Learning
url https://arxiv.org/abs/2512.23763