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Auteurs principaux: Yang, Kang-Chung, Yuan, Shinsheng
Format: Preprint
Publié: 2025
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Accès en ligne:https://arxiv.org/abs/2512.23764
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author Yang, Kang-Chung
Yuan, Shinsheng
author_facet Yang, Kang-Chung
Yuan, Shinsheng
contents In epidemiological research, modeling the cumulative effects of time-dependent exposures on survival outcomes presents a challenge due to their intricate temporal dynamics. Conventional spline-based statistical methods, though effective, require repeated data transformation for each spline parameter tuning, with survival analysis computations relying on the entire dataset, posing difficulties for large datasets. Meanwhile, existing neural network-based survival analysis methods focus on accuracy but often overlook the interpretability of cumulative exposure patterns. To bridge this gap, we introduce CENNSurv, a novel deep learning approach that captures dynamic risk relationships from time-dependent data. Evaluated on two diverse real-world datasets, CENNSurv revealed a multi-year lagged association between chronic environmental exposure and a critical survival outcome, as well as a critical short-term behavioral shift prior to subscription lapse. This demonstrates CENNSurv's ability to model complex temporal patterns with improved scalability. CENNSurv provides researchers studying cumulative effects a practical tool with interpretable insights.
format Preprint
id arxiv_https___arxiv_org_abs_2512_23764
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Exploring Cumulative Effects in Survival Data Using Deep Learning Networks
Yang, Kang-Chung
Yuan, Shinsheng
Machine Learning
In epidemiological research, modeling the cumulative effects of time-dependent exposures on survival outcomes presents a challenge due to their intricate temporal dynamics. Conventional spline-based statistical methods, though effective, require repeated data transformation for each spline parameter tuning, with survival analysis computations relying on the entire dataset, posing difficulties for large datasets. Meanwhile, existing neural network-based survival analysis methods focus on accuracy but often overlook the interpretability of cumulative exposure patterns. To bridge this gap, we introduce CENNSurv, a novel deep learning approach that captures dynamic risk relationships from time-dependent data. Evaluated on two diverse real-world datasets, CENNSurv revealed a multi-year lagged association between chronic environmental exposure and a critical survival outcome, as well as a critical short-term behavioral shift prior to subscription lapse. This demonstrates CENNSurv's ability to model complex temporal patterns with improved scalability. CENNSurv provides researchers studying cumulative effects a practical tool with interpretable insights.
title Exploring Cumulative Effects in Survival Data Using Deep Learning Networks
topic Machine Learning
url https://arxiv.org/abs/2512.23764