Protocellular energetics: Free energy estimates for all metabolic, self-assembly and vesicle fission processes
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arXiv
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| Format: | Preprint |
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2025
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| author | Rasmussen, Steen Frederiksen, Thomas Imai, Masayuki Mansy, Sheref S. Muller, Sabine Grzelczak, Marek |
| author_facet | Rasmussen, Steen Frederiksen, Thomas Imai, Masayuki Mansy, Sheref S. Muller, Sabine Grzelczak, Marek |
| contents | As minimal cells or protocells are dramatically simpler than modern unicells it is possible to quantitatively estimate free energy changes for every process in the lifecycle of a protocell and compare these with estimates of the free energy changes for lifecycles in modern unicells. We present quantitative estimates of all metabolic changes in part by new density function theory (DFT) estimations, in part by compiling previously measured or estimated free energy changes, and in part by new thermodynamic calculations for all self-assembly, vesicle bending, and fission energies. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_24095 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Protocellular energetics: Free energy estimates for all metabolic, self-assembly and vesicle fission processes Rasmussen, Steen Frederiksen, Thomas Imai, Masayuki Mansy, Sheref S. Muller, Sabine Grzelczak, Marek Biological Physics As minimal cells or protocells are dramatically simpler than modern unicells it is possible to quantitatively estimate free energy changes for every process in the lifecycle of a protocell and compare these with estimates of the free energy changes for lifecycles in modern unicells. We present quantitative estimates of all metabolic changes in part by new density function theory (DFT) estimations, in part by compiling previously measured or estimated free energy changes, and in part by new thermodynamic calculations for all self-assembly, vesicle bending, and fission energies. |
| title | Protocellular energetics: Free energy estimates for all metabolic, self-assembly and vesicle fission processes |
| topic | Biological Physics |
| url | https://arxiv.org/abs/2512.24095 |