First Positronium Lifetime Imaging using $^{52}$Mn and $^{55}$Co with a plastic-based PET scanner
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arXiv
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| Natura: | Preprint |
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2025
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| author | Das, Manish Sharma, Sushil Beyene, Ermias Yitayew Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kubat, Karol Kumar, Deepak Kundu, Sumit Kumar Venadan, Anoop Kunimmal Lisowski, Edward Lisowski, Filip Medrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Anand Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej Rädler, Martin Rathod, Narendra Razzaq, Noman Rominger, Axel Shi, Kuangyu Skurzok, Magdalena Słotwiński, Maciej Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Stępień, Ewa Ł. Moskal, Paweł |
| author_facet | Das, Manish Sharma, Sushil Beyene, Ermias Yitayew Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kubat, Karol Kumar, Deepak Kundu, Sumit Kumar Venadan, Anoop Kunimmal Lisowski, Edward Lisowski, Filip Medrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Anand Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej Rädler, Martin Rathod, Narendra Razzaq, Noman Rominger, Axel Shi, Kuangyu Skurzok, Magdalena Słotwiński, Maciej Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Stępień, Ewa Ł. Moskal, Paweł |
| contents | Positronium Lifetime Imaging (PLI) extends positron emission tomography by using the lifetime of positronium atoms as a probe of tissue molecular architecture. In this work, we report the first PLI measurements performed with $^{52}$Mn and $^{55}$Co using the modular J-PET. Four samples were studied in each experiment: two Certified Reference Materials (polycarbonate and fused silica) and two human tissues (cardiac myxoma and adipose). The selection of PLI events was based on the registration of two 511~keV annihilation photons and one prompt gamma in triple coincidence. From the resulting lifetime spectra we extracted the mean ortho-positronium lifetime $τ_{\text{oPs}}$ and the mean positron lifetime $ΔT_{\text{mean}}$ for each sample. The measured values of $τ_{\text{oPs}}$ in polycarbonate using both isotopes matches well with the certified reference values. Furthermore, $^{55}$Co reproduced identical results for fused-silica measurements at their respective uncertainty levels. In contrast, measurements with $^{52}$Mn in fused silica show a minor deviation, which could be caused by the Parafilm spacer. In myxoma and adipose tissue, the reduced $τ_{\text{oPs}}$ values are mainly linked to the long storage history of the samples rather than to the choice of isotope. Comparing peak-to-background ratios and spectral purity, $^{55}$Co provides cleaner PLI data under the same experimental conditions. Although $^{52}$Mn offers a longer half-life and a multi gamma cascade enhancing $β^{+}$ + $γ$ coincidences, but at the expense of higher background. In this study, we demonstrate that the applied selection criteria on the data measured with the modular J-PET can be used for PLI studies even with radionuclides with complex decay patterns. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_24261 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | First Positronium Lifetime Imaging using $^{52}$Mn and $^{55}$Co with a plastic-based PET scanner Das, Manish Sharma, Sushil Beyene, Ermias Yitayew Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kubat, Karol Kumar, Deepak Kundu, Sumit Kumar Venadan, Anoop Kunimmal Lisowski, Edward Lisowski, Filip Medrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Anand Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej Rädler, Martin Rathod, Narendra Razzaq, Noman Rominger, Axel Shi, Kuangyu Skurzok, Magdalena Słotwiński, Maciej Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Stępień, Ewa Ł. Moskal, Paweł Medical Physics Positronium Lifetime Imaging (PLI) extends positron emission tomography by using the lifetime of positronium atoms as a probe of tissue molecular architecture. In this work, we report the first PLI measurements performed with $^{52}$Mn and $^{55}$Co using the modular J-PET. Four samples were studied in each experiment: two Certified Reference Materials (polycarbonate and fused silica) and two human tissues (cardiac myxoma and adipose). The selection of PLI events was based on the registration of two 511~keV annihilation photons and one prompt gamma in triple coincidence. From the resulting lifetime spectra we extracted the mean ortho-positronium lifetime $τ_{\text{oPs}}$ and the mean positron lifetime $ΔT_{\text{mean}}$ for each sample. The measured values of $τ_{\text{oPs}}$ in polycarbonate using both isotopes matches well with the certified reference values. Furthermore, $^{55}$Co reproduced identical results for fused-silica measurements at their respective uncertainty levels. In contrast, measurements with $^{52}$Mn in fused silica show a minor deviation, which could be caused by the Parafilm spacer. In myxoma and adipose tissue, the reduced $τ_{\text{oPs}}$ values are mainly linked to the long storage history of the samples rather than to the choice of isotope. Comparing peak-to-background ratios and spectral purity, $^{55}$Co provides cleaner PLI data under the same experimental conditions. Although $^{52}$Mn offers a longer half-life and a multi gamma cascade enhancing $β^{+}$ + $γ$ coincidences, but at the expense of higher background. In this study, we demonstrate that the applied selection criteria on the data measured with the modular J-PET can be used for PLI studies even with radionuclides with complex decay patterns. |
| title | First Positronium Lifetime Imaging using $^{52}$Mn and $^{55}$Co with a plastic-based PET scanner |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2512.24261 |