Copertina

Salvato in:
Dettagli Bibliografici
Autori principali: Zeng, Biao-Feng, Wang, Zian, Yang, Yuxin, Ma, Xufei, Xu, Liang, Shen, Yi, Yi, Long, Fang, Yizheng, Tian, Ye, Zheng, Zhenrong, Cui, Yudong, Cao, Ji, Bai, Ge, Ye, Weixiang, Wang, Pan, Kuang, Cuifang, Edel, Joshua B., Ivanov, Aleksandar P., Liu, Xu, Tang, Longhua
Natura: Preprint
Pubblicazione: 2026
Soggetti:
Biological Physics
Accesso online:https://arxiv.org/abs/2601.01560
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Sommario:
  • Biological electron transfer (ET) relies on quantum mechanical tunnelling through a dynamically folded protein. Yet, the spatiotemporal coupling between structural fluctuations and electron flux remains poorly understood, largely due to limitations in existing experimental techniques, such as ensemble averaging and non-physiological operating conditions. Here, we introduce a quantum tunnelling-integrated optoplasmonic nanotrap (QTOP-trap), an optoelectronic platform that combines plasmonic optical trapping with real-time quantum tunnelling measurements. This label-free approach enables single-molecule resolution of protein conductance in physiological electrolytes, achieving sub-3 nm spatial precision and 10-μs temporal resolution. By synchronising optoelectronic measurements, QTOP-trap resolves protein-specific conductance signatures and directly correlates tertiary structure dynamics with conductance using a "protein switch" strategy. This methodology establishes a universal framework for dissecting non-equilibrium ET mechanisms in individual conformational-active proteins, with broad implications for bioenergetics research and biomimetic quantum device design.

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