Allostery Beyond Amplification: Temporal Regulation of Signaling Information
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arXiv
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| Autores principales: | , , |
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| Formato: | Preprint |
| Publicado: |
2026
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| _version_ | 1866915713830092800 |
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| author | Pessoa, Pedro Pressé, Steve Ozkan, S. Banu |
| author_facet | Pessoa, Pedro Pressé, Steve Ozkan, S. Banu |
| contents | Allostery is a fundamental mechanism of protein regulation and is commonly interpreted as modulating enzymatic activity or product abundance. Here we show that this view is incomplete. Using a stochastic model of allosteric regulation combined with an information-theoretic analysis, we quantify the mutual information between an enzyme's regulatory state and the states of downstream signaling components. Beyond controlling steady-state production levels, allostery also regulates the timing and duration over which information is transmitted. By tuning the temporal operating regime of signaling pathways, allosteric regulation enables distinct dynamical outcomes from identical molecular components, providing a physical mechanism for temporal information flow, signaling specificity, and coordination without changes in metabolic pathways. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_01850 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Allostery Beyond Amplification: Temporal Regulation of Signaling Information Pessoa, Pedro Pressé, Steve Ozkan, S. Banu Molecular Networks Dynamical Systems Biological Physics Chemical Physics Allostery is a fundamental mechanism of protein regulation and is commonly interpreted as modulating enzymatic activity or product abundance. Here we show that this view is incomplete. Using a stochastic model of allosteric regulation combined with an information-theoretic analysis, we quantify the mutual information between an enzyme's regulatory state and the states of downstream signaling components. Beyond controlling steady-state production levels, allostery also regulates the timing and duration over which information is transmitted. By tuning the temporal operating regime of signaling pathways, allosteric regulation enables distinct dynamical outcomes from identical molecular components, providing a physical mechanism for temporal information flow, signaling specificity, and coordination without changes in metabolic pathways. |
| title | Allostery Beyond Amplification: Temporal Regulation of Signaling Information |
| topic | Molecular Networks Dynamical Systems Biological Physics Chemical Physics |
| url | https://arxiv.org/abs/2601.01850 |