Biomechanically Informed Image Registration for Patient-Specific Aortic Valve Strain Analysis
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2026
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| author | Nakhaei, Mohsen Pouch, Alison Amin, Silvani Daemer, Matthew Herz, Christian Yushkevich, Natalie Ghofaily, Lourdes Al Desai, Nimesh Bavaria, Joseph Jolley, Matthew Wu, Wensi |
| author_facet | Nakhaei, Mohsen Pouch, Alison Amin, Silvani Daemer, Matthew Herz, Christian Yushkevich, Natalie Ghofaily, Lourdes Al Desai, Nimesh Bavaria, Joseph Jolley, Matthew Wu, Wensi |
| contents | Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading, increase strain, and accelerate disease progression. Accurate patient-specific characterization of valve geometry and deformation is therefore essential for predicting disease progression and guiding durable repair. Current imaging and computational methods often fail to capture rapid valve motion and complex patient-specific features, limiting precise biomechanical assessment. To address these limitations, we developed an image registration framework coupled with the finite element method (FEM) to improve AV tracking and biomechanical evaluation. The valve geometries derived from 4D echocardiography and CT were used to simulate AV closure and generate intermediate deformation states. These FEM-generated states facilitated leaflet tracking, while image registration corrected misalignment between simulations and imaging data. In 20 patients, FEM-augmented registration improved accuracy by 40% compared with direct registration. This improvement enabled more reliable strain estimation by measuring leaflet deformation directly from imaging and reducing uncertainties associated with boundary conditions and material assumptions. Areal, Green-Lagrange, and deviatoric strains were quantified in adult trileaflet/bicuspid valves, as well as pediatric patients, revealing distinct deformation patterns across valve groups. Convergence in mean deviatoric strain between adult trileaflet and pediatric valves suggests volumetric deformation underlies age- and size-related differences in AV mechanics. The FEM-augmented registration enhances tracking and biomechanical evaluation accuracy, providing clinically relevant insights into patient-specific AV deformation to support individualized medical and intervention planning. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_04375 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Biomechanically Informed Image Registration for Patient-Specific Aortic Valve Strain Analysis Nakhaei, Mohsen Pouch, Alison Amin, Silvani Daemer, Matthew Herz, Christian Yushkevich, Natalie Ghofaily, Lourdes Al Desai, Nimesh Bavaria, Joseph Jolley, Matthew Wu, Wensi Quantitative Methods Applied Physics Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading, increase strain, and accelerate disease progression. Accurate patient-specific characterization of valve geometry and deformation is therefore essential for predicting disease progression and guiding durable repair. Current imaging and computational methods often fail to capture rapid valve motion and complex patient-specific features, limiting precise biomechanical assessment. To address these limitations, we developed an image registration framework coupled with the finite element method (FEM) to improve AV tracking and biomechanical evaluation. The valve geometries derived from 4D echocardiography and CT were used to simulate AV closure and generate intermediate deformation states. These FEM-generated states facilitated leaflet tracking, while image registration corrected misalignment between simulations and imaging data. In 20 patients, FEM-augmented registration improved accuracy by 40% compared with direct registration. This improvement enabled more reliable strain estimation by measuring leaflet deformation directly from imaging and reducing uncertainties associated with boundary conditions and material assumptions. Areal, Green-Lagrange, and deviatoric strains were quantified in adult trileaflet/bicuspid valves, as well as pediatric patients, revealing distinct deformation patterns across valve groups. Convergence in mean deviatoric strain between adult trileaflet and pediatric valves suggests volumetric deformation underlies age- and size-related differences in AV mechanics. The FEM-augmented registration enhances tracking and biomechanical evaluation accuracy, providing clinically relevant insights into patient-specific AV deformation to support individualized medical and intervention planning. |
| title | Biomechanically Informed Image Registration for Patient-Specific Aortic Valve Strain Analysis |
| topic | Quantitative Methods Applied Physics |
| url | https://arxiv.org/abs/2601.04375 |