AntibodyDesignBFN: High-Fidelity Fixed-Backbone Antibody Design via Discrete Bayesian Flow Networks
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arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2026
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| _version_ | 1866915811769188352 |
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| author | Hu, Yue Tao, Feng Wang, Junqing Liu, YingChao |
| author_facet | Hu, Yue Tao, Feng Wang, Junqing Liu, YingChao |
| contents | The computational design of antibodies with high specificity and affinity is a cornerstone of modern therapeutic development. While deep generative models have demonstrated potential, they often struggle to balance high-fidelity geometric conditioning with the discrete nature of amino acid sequences. In this work, we present AntibodyDesignBFN, a novel framework for fixed-backbone antibody design based on Discrete Bayesian Flow Networks (BFN). Unlike standard diffusion models, BFNs operate on a continuous probability simplex, enabling a fully differentiable generative process that seamlessly integrates geometric gradients. By combining a lightweight Geometric Transformer with Invariant Point Attention (IPA) and a resource-efficient training strategy, our model establishes a new state-of-the-art. Evaluations on a rigorous 2025 temporal test set (43 complexes) demonstrate that AntibodyDesignBFN achieves an unprecedented Amino Acid Recovery(AAR) of 67.8%, significantly outperforming leading graph-based baselines. Furthermore, the model is highly efficient, enabling millisecond-scale inference on consumer-grade hardware. AntibodyDesignBFN thus offers a powerful, accessible, and mathematically robust framework for next generation antibody engineering. Code and model checkpoints are available at https://github.com/YueHuLab/AntibodyDesignBFN and https://huggingface.co/YueHuLab/AntibodyDesignBFN. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_05605 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | AntibodyDesignBFN: High-Fidelity Fixed-Backbone Antibody Design via Discrete Bayesian Flow Networks Hu, Yue Tao, Feng Wang, Junqing Liu, YingChao Quantitative Methods 92C40, 68T07, 62F15 The computational design of antibodies with high specificity and affinity is a cornerstone of modern therapeutic development. While deep generative models have demonstrated potential, they often struggle to balance high-fidelity geometric conditioning with the discrete nature of amino acid sequences. In this work, we present AntibodyDesignBFN, a novel framework for fixed-backbone antibody design based on Discrete Bayesian Flow Networks (BFN). Unlike standard diffusion models, BFNs operate on a continuous probability simplex, enabling a fully differentiable generative process that seamlessly integrates geometric gradients. By combining a lightweight Geometric Transformer with Invariant Point Attention (IPA) and a resource-efficient training strategy, our model establishes a new state-of-the-art. Evaluations on a rigorous 2025 temporal test set (43 complexes) demonstrate that AntibodyDesignBFN achieves an unprecedented Amino Acid Recovery(AAR) of 67.8%, significantly outperforming leading graph-based baselines. Furthermore, the model is highly efficient, enabling millisecond-scale inference on consumer-grade hardware. AntibodyDesignBFN thus offers a powerful, accessible, and mathematically robust framework for next generation antibody engineering. Code and model checkpoints are available at https://github.com/YueHuLab/AntibodyDesignBFN and https://huggingface.co/YueHuLab/AntibodyDesignBFN. |
| title | AntibodyDesignBFN: High-Fidelity Fixed-Backbone Antibody Design via Discrete Bayesian Flow Networks |
| topic | Quantitative Methods 92C40, 68T07, 62F15 |
| url | https://arxiv.org/abs/2601.05605 |