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| Main Authors: | , , , , , |
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| Format: | Preprint |
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2026
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| Online Access: | https://arxiv.org/abs/2601.05809 |
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| _version_ | 1866909985795997696 |
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| author | Scarabelli, Romain Abbasi, Mehdi Gary-Bobo, Magali Drouet, Christophe Leonetti, Marc Al-Kattan, Ahmed |
| author_facet | Scarabelli, Romain Abbasi, Mehdi Gary-Bobo, Magali Drouet, Christophe Leonetti, Marc Al-Kattan, Ahmed |
| contents | Electrospun poly(ε-caprolactone) (PCL)nanofibrous mats are widely considered for blood-contacting wound dressings and small-diameter vascular applications; however, their intrinsic hydrophobicity limits rapid wetting and controlled interaction with blood. In this work, we modulate the interfacial response of PCL nanofibers by incorporating oxide-shelled silicon nanoparticles (SiNPs) synthesized by pulsed laser ablation in liquid, a ligand-free approach that avoids organic stabilizers and preserves surface reactivity. Two composite architectures were designed: SiNPs embedded within the fiber bulk (PAC1,4,16) and SiNPs preferentially exposed at the fiber surface (SPAC1,4,16), with systematically increasing nanoparticle loadings. Structural characterization confirmed the retention of a homogeneous fibrous morphology and the targeted nanoparticle distribution. The dynamic interaction with whole blood was quantified using time-resolved contact-angle measurements, complemented by top-view optical microscopy and three-dimensional profilometry of dried droplets. Pristine PCL remained strongly hydrophobic whereas a hydrophilic PCL functionalized with APTES showed rapid spreading. Incorporation of SiNPs within the fiber volume led to only a moderate enhancement of wettability, and dried droplets retained compact morphologies with limited spreading. In contrast, surface-decorated mats displayed a sharp, concentration-dependent transition toward highly wettable behavior: for SPAC16, the contact angle fell below 20, droplet profiles became markedly flattened, and microscopy revealed extended plasma-rich regions surrounding a red-cell-rich core, indicative of pronounced phase separation within the nanofibrous network. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2601_05809 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Early bloodmaterial interfacial events and capillary transport on nanoparticle modified nanofibers Scarabelli, Romain Abbasi, Mehdi Gary-Bobo, Magali Drouet, Christophe Leonetti, Marc Al-Kattan, Ahmed Soft Condensed Matter Materials Science Electrospun poly(ε-caprolactone) (PCL)nanofibrous mats are widely considered for blood-contacting wound dressings and small-diameter vascular applications; however, their intrinsic hydrophobicity limits rapid wetting and controlled interaction with blood. In this work, we modulate the interfacial response of PCL nanofibers by incorporating oxide-shelled silicon nanoparticles (SiNPs) synthesized by pulsed laser ablation in liquid, a ligand-free approach that avoids organic stabilizers and preserves surface reactivity. Two composite architectures were designed: SiNPs embedded within the fiber bulk (PAC1,4,16) and SiNPs preferentially exposed at the fiber surface (SPAC1,4,16), with systematically increasing nanoparticle loadings. Structural characterization confirmed the retention of a homogeneous fibrous morphology and the targeted nanoparticle distribution. The dynamic interaction with whole blood was quantified using time-resolved contact-angle measurements, complemented by top-view optical microscopy and three-dimensional profilometry of dried droplets. Pristine PCL remained strongly hydrophobic whereas a hydrophilic PCL functionalized with APTES showed rapid spreading. Incorporation of SiNPs within the fiber volume led to only a moderate enhancement of wettability, and dried droplets retained compact morphologies with limited spreading. In contrast, surface-decorated mats displayed a sharp, concentration-dependent transition toward highly wettable behavior: for SPAC16, the contact angle fell below 20, droplet profiles became markedly flattened, and microscopy revealed extended plasma-rich regions surrounding a red-cell-rich core, indicative of pronounced phase separation within the nanofibrous network. |
| title | Early bloodmaterial interfacial events and capillary transport on nanoparticle modified nanofibers |
| topic | Soft Condensed Matter Materials Science |
| url | https://arxiv.org/abs/2601.05809 |