Simulations Predict Improved Valve Performance Without Direct Leaflet Intervention After Neonatal Truncus Arteriosus Repair
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arXiv
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Preprint |
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2026
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| _version_ | 1866914254616002560 |
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| author | Bornemann, Karoline-Marie Choi, Perry S. Huber, Jay Reed, Alexander K. Sharir, Amit Maskatia, Shiraz A. Marsden, Alison L. Ma, Michael R. Kaiser, Alexander D. |
| author_facet | Bornemann, Karoline-Marie Choi, Perry S. Huber, Jay Reed, Alexander K. Sharir, Amit Maskatia, Shiraz A. Marsden, Alison L. Ma, Michael R. Kaiser, Alexander D. |
| contents | Truncus arteriosus (TA) is a rare and severe congenital heart disease. Quadricuspid valve morphology occurs in 25% of all TA patients and is linked to regurgitation and increased risk of re-operation. It remains unclear how hemodynamic changes after TA repair alter valve performance. This study simulated pre- and postoperative conditions in a neonatal TA patient to investigate valve performance without direct intervention. We hypothesize that valve performance before and after truncal repair can be predicted in-silico, matching in-vivo imaging and identifying mechanisms how hemodynamic changes after repair will reduce valve regurgitation without direct intervention. Pre- and postoperative CT images of a neonatal patient with quadricuspid valve were segmented. Free edge length and geometric height from the patient's echocardiogram were used to model the valve. For the preoperative condition, ventricular pressures were set equal modeling an unrestricted ventricular septal defect. Systemic and pulmonary resistances were tuned based on the patient's Qp:Qs ratio. For the postoperative condition, boundary conditions were modified to mimic patient-specific hemodynamics after TA repair. The preoperative simulation confirmed mild valve regurgitation seen in-vivo. Interaction between asymmetric flow and surrounding vessel resulted in asymmetric opening and closing. Poor central coaptation led to a central regurgitant jet toward the septum. Altered postoperative hemodynamics improved coaptation and eliminated regurgitation, as seen in-vivo. This modeling approach reproduced in-vivo pre- and postoperative valve performance and identified mechanisms improving coaptation after TA repair. TA repair led to elimination of regurgitation due to enhanced central coaptation. Thus, altered postoperative hemodynamic conditions after TA repair may improve valve performance without direct leaflet intervention. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_08932 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Simulations Predict Improved Valve Performance Without Direct Leaflet Intervention After Neonatal Truncus Arteriosus Repair Bornemann, Karoline-Marie Choi, Perry S. Huber, Jay Reed, Alexander K. Sharir, Amit Maskatia, Shiraz A. Marsden, Alison L. Ma, Michael R. Kaiser, Alexander D. Tissues and Organs 92C35 (Primary), 92C50, 92C32, 76Z05 (Secondary) J.3.1 Truncus arteriosus (TA) is a rare and severe congenital heart disease. Quadricuspid valve morphology occurs in 25% of all TA patients and is linked to regurgitation and increased risk of re-operation. It remains unclear how hemodynamic changes after TA repair alter valve performance. This study simulated pre- and postoperative conditions in a neonatal TA patient to investigate valve performance without direct intervention. We hypothesize that valve performance before and after truncal repair can be predicted in-silico, matching in-vivo imaging and identifying mechanisms how hemodynamic changes after repair will reduce valve regurgitation without direct intervention. Pre- and postoperative CT images of a neonatal patient with quadricuspid valve were segmented. Free edge length and geometric height from the patient's echocardiogram were used to model the valve. For the preoperative condition, ventricular pressures were set equal modeling an unrestricted ventricular septal defect. Systemic and pulmonary resistances were tuned based on the patient's Qp:Qs ratio. For the postoperative condition, boundary conditions were modified to mimic patient-specific hemodynamics after TA repair. The preoperative simulation confirmed mild valve regurgitation seen in-vivo. Interaction between asymmetric flow and surrounding vessel resulted in asymmetric opening and closing. Poor central coaptation led to a central regurgitant jet toward the septum. Altered postoperative hemodynamics improved coaptation and eliminated regurgitation, as seen in-vivo. This modeling approach reproduced in-vivo pre- and postoperative valve performance and identified mechanisms improving coaptation after TA repair. TA repair led to elimination of regurgitation due to enhanced central coaptation. Thus, altered postoperative hemodynamic conditions after TA repair may improve valve performance without direct leaflet intervention. |
| title | Simulations Predict Improved Valve Performance Without Direct Leaflet Intervention After Neonatal Truncus Arteriosus Repair |
| topic | Tissues and Organs 92C35 (Primary), 92C50, 92C32, 76Z05 (Secondary) J.3.1 |
| url | https://arxiv.org/abs/2601.08932 |