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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2601.10020 |
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| _version_ | 1866908767240585216 |
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| author | Qian, Lingfei Giuffre, Mauro Wang, Yan He, Huan Xie, Qianqian Ai, Xuguang Peng, Xeuqing Ma, Fan Weng, Ruey-Ling Wright, Donald Wang, Adan Chen, Qingyu Keloth, Vipina K. Xu, Hua |
| author_facet | Qian, Lingfei Giuffre, Mauro Wang, Yan He, Huan Xie, Qianqian Ai, Xuguang Peng, Xeuqing Ma, Fan Weng, Ruey-Ling Wright, Donald Wang, Adan Chen, Qingyu Keloth, Vipina K. Xu, Hua |
| contents | Clinical decision-making increasingly relies on timely and context-aware access to patient information within Electronic Health Records (EHRs), yet most existing natural language question-answering (QA) systems are evaluated solely on benchmark datasets, limiting their practical relevance. To overcome this limitation, we introduce EHRNavigator, a multi-agent framework that harnesses AI agents to perform patient-level question answering across heterogeneous and multimodal EHR data. We assessed its performance using both public benchmark and institutional datasets under realistic hospital conditions characterized by diverse schemas, temporal reasoning demands, and multimodal evidence integration. Through quantitative evaluation and clinician-validated chart review, EHRNavigator demonstrated strong generalization, achieving 86% accuracy on real-world cases while maintaining clinically acceptable response times. Overall, these findings confirm that EHRNavigator effectively bridges the gap between benchmark evaluation and clinical deployment, offering a robust, adaptive, and efficient solution for real-world EHR question answering. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_10020 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | EHRNavigator: A Multi-Agent System for Patient-Level Clinical Question Answering over Heterogeneous Electronic Health Records Qian, Lingfei Giuffre, Mauro Wang, Yan He, Huan Xie, Qianqian Ai, Xuguang Peng, Xeuqing Ma, Fan Weng, Ruey-Ling Wright, Donald Wang, Adan Chen, Qingyu Keloth, Vipina K. Xu, Hua Computation and Language Clinical decision-making increasingly relies on timely and context-aware access to patient information within Electronic Health Records (EHRs), yet most existing natural language question-answering (QA) systems are evaluated solely on benchmark datasets, limiting their practical relevance. To overcome this limitation, we introduce EHRNavigator, a multi-agent framework that harnesses AI agents to perform patient-level question answering across heterogeneous and multimodal EHR data. We assessed its performance using both public benchmark and institutional datasets under realistic hospital conditions characterized by diverse schemas, temporal reasoning demands, and multimodal evidence integration. Through quantitative evaluation and clinician-validated chart review, EHRNavigator demonstrated strong generalization, achieving 86% accuracy on real-world cases while maintaining clinically acceptable response times. Overall, these findings confirm that EHRNavigator effectively bridges the gap between benchmark evaluation and clinical deployment, offering a robust, adaptive, and efficient solution for real-world EHR question answering. |
| title | EHRNavigator: A Multi-Agent System for Patient-Level Clinical Question Answering over Heterogeneous Electronic Health Records |
| topic | Computation and Language |
| url | https://arxiv.org/abs/2601.10020 |