A Bayesian Discrete Framework for Enhancing Decision-Making Processes in Clinical Trial Designs and Evaluations
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arXiv
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| Hauptverfasser: | , , , |
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| Format: | Preprint |
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2026
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| _version_ | 1866912826502676480 |
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| author | Pramanik, Paramahansa Maity, Arnab Kumar Mandal, Anjan Robinson, Haley Kate |
| author_facet | Pramanik, Paramahansa Maity, Arnab Kumar Mandal, Anjan Robinson, Haley Kate |
| contents | This study examines the application of Bayesian approach in the context of clinical trials, emphasizing their increasing importance in contemporary biomedical research. While conventional frequentist approach provides a foundational basis for analysis, it often lacks the flexibility to integrate prior knowledge, which can constrain its effectiveness in adaptive settings. In contrast, Bayesian methods enable continual refinement of statistical inferences through the assimilation of accumulating evidence, thereby supporting more informed decision-making and improving the reliability of trial findings. This paper also considers persistent challenges in clinical investigations, including replication difficulties and the misinterpretation of statistical results, suggesting that Bayesian strategies may offer a path toward enhanced analytical robustness. Moreover, discrete probability models, specifically the Binomial, Poisson, and Negative Binomial distributions are explored for their suitability in modeling clinical endpoints, particularly in trials involving binary responses or data with overdispersion. The discussion further incorporates Bayesian networks and Bayesian estimation techniques, with a comparative evaluation against maximum likelihood estimation to elucidate differences in inferential behavior and practical implementation. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_10615 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | A Bayesian Discrete Framework for Enhancing Decision-Making Processes in Clinical Trial Designs and Evaluations Pramanik, Paramahansa Maity, Arnab Kumar Mandal, Anjan Robinson, Haley Kate Methodology Applications This study examines the application of Bayesian approach in the context of clinical trials, emphasizing their increasing importance in contemporary biomedical research. While conventional frequentist approach provides a foundational basis for analysis, it often lacks the flexibility to integrate prior knowledge, which can constrain its effectiveness in adaptive settings. In contrast, Bayesian methods enable continual refinement of statistical inferences through the assimilation of accumulating evidence, thereby supporting more informed decision-making and improving the reliability of trial findings. This paper also considers persistent challenges in clinical investigations, including replication difficulties and the misinterpretation of statistical results, suggesting that Bayesian strategies may offer a path toward enhanced analytical robustness. Moreover, discrete probability models, specifically the Binomial, Poisson, and Negative Binomial distributions are explored for their suitability in modeling clinical endpoints, particularly in trials involving binary responses or data with overdispersion. The discussion further incorporates Bayesian networks and Bayesian estimation techniques, with a comparative evaluation against maximum likelihood estimation to elucidate differences in inferential behavior and practical implementation. |
| title | A Bayesian Discrete Framework for Enhancing Decision-Making Processes in Clinical Trial Designs and Evaluations |
| topic | Methodology Applications |
| url | https://arxiv.org/abs/2601.10615 |