Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2026
|
| Subjects: | |
| Online Access: | https://arxiv.org/abs/2601.13559 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866911386996572160 |
|---|---|
| author | Hui, Sun Yanfeng, Ding Ma, Huidong Xu, Chang Jin, Keyan Zu, Lizheng Zhong, Cheng Liu, xiaoguang Wang, Gang Cai, Wentong |
| author_facet | Hui, Sun Yanfeng, Ding Ma, Huidong Xu, Chang Jin, Keyan Zu, Lizheng Zhong, Cheng Liu, xiaoguang Wang, Gang Cai, Wentong |
| contents | Lossless compression has made significant advancements in Genomics Data (GD) storage, sharing and management. Current learning-based methods are non-evolvable with problems of low-level compression modeling, limited adaptability, and user-unfriendly interface. To this end, we propose AgentGC, the first evolutionary Agent-based GD Compressor, consisting of 3 layers with multi-agent named Leader and Worker. Specifically, the 1) User layer provides a user-friendly interface via Leader combined with LLM; 2) Cognitive layer, driven by the Leader, integrates LLM to consider joint optimization of algorithm-dataset-system, addressing the issues of low-level modeling and limited adaptability; and 3) Compression layer, headed by Worker, performs compression & decompression via a automated multi-knowledge learning-based compression framework. On top of AgentGC, we design 3 modes to support diverse scenarios: CP for compression-ratio priority, TP for throughput priority, and BM for balanced mode. Compared with 14 baselines on 9 datasets, the average compression ratios gains are 16.66%, 16.11%, and 16.33%, the throughput gains are 4.73x, 9.23x, and 9.15x, respectively. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_13559 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | AgentGC: Evolutionary Learning-based Lossless Compression for Genomics Data with LLM-driven Multiple Agent Hui, Sun Yanfeng, Ding Ma, Huidong Xu, Chang Jin, Keyan Zu, Lizheng Zhong, Cheng Liu, xiaoguang Wang, Gang Cai, Wentong Artificial Intelligence Lossless compression has made significant advancements in Genomics Data (GD) storage, sharing and management. Current learning-based methods are non-evolvable with problems of low-level compression modeling, limited adaptability, and user-unfriendly interface. To this end, we propose AgentGC, the first evolutionary Agent-based GD Compressor, consisting of 3 layers with multi-agent named Leader and Worker. Specifically, the 1) User layer provides a user-friendly interface via Leader combined with LLM; 2) Cognitive layer, driven by the Leader, integrates LLM to consider joint optimization of algorithm-dataset-system, addressing the issues of low-level modeling and limited adaptability; and 3) Compression layer, headed by Worker, performs compression & decompression via a automated multi-knowledge learning-based compression framework. On top of AgentGC, we design 3 modes to support diverse scenarios: CP for compression-ratio priority, TP for throughput priority, and BM for balanced mode. Compared with 14 baselines on 9 datasets, the average compression ratios gains are 16.66%, 16.11%, and 16.33%, the throughput gains are 4.73x, 9.23x, and 9.15x, respectively. |
| title | AgentGC: Evolutionary Learning-based Lossless Compression for Genomics Data with LLM-driven Multiple Agent |
| topic | Artificial Intelligence |
| url | https://arxiv.org/abs/2601.13559 |