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Main Authors: Sadhukhan, Payel, Gupta, Samrat, Ghosh, Subhasis, Chakraborty, Tanujit
Format: Preprint
Published: 2026
Subjects:
Online Access:https://arxiv.org/abs/2601.14062
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author Sadhukhan, Payel
Gupta, Samrat
Ghosh, Subhasis
Chakraborty, Tanujit
author_facet Sadhukhan, Payel
Gupta, Samrat
Ghosh, Subhasis
Chakraborty, Tanujit
contents Healthcare sector indices consolidate the economic health of pharmaceutical, biotechnology, and healthcare service firms. The short-term movements in these indices are closely intertwined with capital allocation decisions affecting research and development investment, drug availability, and long-term health outcomes. This research investigates whether historical open-high-low-close (OHLC) index data contain sufficient information for predicting the directional movement of the opening index on the subsequent trading day. The problem is formulated as a supervised classification task involving a one-step-ahead rolling window. A diverse feature set is constructed, comprising original prices, volatility-based technical indicators, and a novel class of nowcasting features derived from mutual OHLC ratios. The framework is evaluated on data from healthcare indices in the U.S. and Indian markets over a five-year period spanning multiple economic phases, including the COVID-19 pandemic. The results demonstrate robust predictive performance, with accuracy exceeding 0.8 and Matthews correlation coefficients above 0.6. Notably, the proposed nowcasting features have emerged as a key determinant of the market movement. We have employed the Shapley-based explainability paradigm to further elucidate the contribution of the features: outcomes reveal the dominant role of the nowcasting features, followed by a more moderate contribution of original prices. This research offers a societal utility: the proposed features and model for short-term forecasting of healthcare indices can reduce information asymmetry and support a more stable and equitable health economy.
format Preprint
id arxiv_https___arxiv_org_abs_2601_14062
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Demystifying the trend of the healthcare index: Is historical price a key driver?
Sadhukhan, Payel
Gupta, Samrat
Ghosh, Subhasis
Chakraborty, Tanujit
Statistical Finance
Applications
Machine Learning
Healthcare sector indices consolidate the economic health of pharmaceutical, biotechnology, and healthcare service firms. The short-term movements in these indices are closely intertwined with capital allocation decisions affecting research and development investment, drug availability, and long-term health outcomes. This research investigates whether historical open-high-low-close (OHLC) index data contain sufficient information for predicting the directional movement of the opening index on the subsequent trading day. The problem is formulated as a supervised classification task involving a one-step-ahead rolling window. A diverse feature set is constructed, comprising original prices, volatility-based technical indicators, and a novel class of nowcasting features derived from mutual OHLC ratios. The framework is evaluated on data from healthcare indices in the U.S. and Indian markets over a five-year period spanning multiple economic phases, including the COVID-19 pandemic. The results demonstrate robust predictive performance, with accuracy exceeding 0.8 and Matthews correlation coefficients above 0.6. Notably, the proposed nowcasting features have emerged as a key determinant of the market movement. We have employed the Shapley-based explainability paradigm to further elucidate the contribution of the features: outcomes reveal the dominant role of the nowcasting features, followed by a more moderate contribution of original prices. This research offers a societal utility: the proposed features and model for short-term forecasting of healthcare indices can reduce information asymmetry and support a more stable and equitable health economy.
title Demystifying the trend of the healthcare index: Is historical price a key driver?
topic Statistical Finance
Applications
Machine Learning
url https://arxiv.org/abs/2601.14062