Inference on the Significance of Modalities in Multimodal Generalized Linear Models

Fuente: arXiv
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Auteurs principaux: Jin, Wanting, Wu, Guorong, Li, Quefeng
Format: Preprint
Publié: 2026
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author Jin, Wanting
Wu, Guorong
Li, Quefeng
author_facet Jin, Wanting
Wu, Guorong
Li, Quefeng
contents Despite the popular of multimodal statistical models, there lacks rigorous statistical inference tools for inferring the significance of a single modality within a multimodal model, especially in high-dimensional models. For high-dimensional multimodal generalized linear models, we propose a novel entropy-based metric, called the expected relative entropy, to quantify the information gain of one modality in addition to all other modalities in the model. We propose a deviance-based statistic to estimate the expected relative entropy, prove that it is consistent and its asymptotic distribution can be approximated by a non-central chi-squared distribution. That enables the calculation of confidence intervals and p-values to assess the significance of the expected relative entropy for a given modality. We numerically evaluate the empirical performance of our proposed inference tool by simulations and apply it to a multimodal neuroimaging dataset to demonstrate its good performance on various high-dimensional multimodal generalized linear models.
format Preprint
id arxiv_https___arxiv_org_abs_2601_16196
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Inference on the Significance of Modalities in Multimodal Generalized Linear Models
Jin, Wanting
Wu, Guorong
Li, Quefeng
Methodology
Despite the popular of multimodal statistical models, there lacks rigorous statistical inference tools for inferring the significance of a single modality within a multimodal model, especially in high-dimensional models. For high-dimensional multimodal generalized linear models, we propose a novel entropy-based metric, called the expected relative entropy, to quantify the information gain of one modality in addition to all other modalities in the model. We propose a deviance-based statistic to estimate the expected relative entropy, prove that it is consistent and its asymptotic distribution can be approximated by a non-central chi-squared distribution. That enables the calculation of confidence intervals and p-values to assess the significance of the expected relative entropy for a given modality. We numerically evaluate the empirical performance of our proposed inference tool by simulations and apply it to a multimodal neuroimaging dataset to demonstrate its good performance on various high-dimensional multimodal generalized linear models.
title Inference on the Significance of Modalities in Multimodal Generalized Linear Models
topic Methodology
url https://arxiv.org/abs/2601.16196