Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution
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arXiv
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| _version_ | 1866915750656081920 |
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| author | Duraffourg, L. Borges, H. Fernandes, M. Beurrier-Bousquet, M. Baraillon, J. Taurel, B. Galudec, J. Le Vianey, K. Maisin, C. Samaison, L. Staroz, F. Dupoy, M. |
| author_facet | Duraffourg, L. Borges, H. Fernandes, M. Beurrier-Bousquet, M. Baraillon, J. Taurel, B. Galudec, J. Le Vianey, K. Maisin, C. Samaison, L. Staroz, F. Dupoy, M. |
| contents | We present a rapid, large-field bimodal imaging platform that integrates conventional brightfield microscopy with a lensless IR imaging scanner, enabling whole-slide IR image stack acquisition in minutes. Using a dedicated deep learning model, we implement an optical HE staining strategy based on subcellular morpho-spectral fingerprinting. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2601_16904 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution Duraffourg, L. Borges, H. Fernandes, M. Beurrier-Bousquet, M. Baraillon, J. Taurel, B. Galudec, J. Le Vianey, K. Maisin, C. Samaison, L. Staroz, F. Dupoy, M. Optics Image and Video Processing Biological Physics We present a rapid, large-field bimodal imaging platform that integrates conventional brightfield microscopy with a lensless IR imaging scanner, enabling whole-slide IR image stack acquisition in minutes. Using a dedicated deep learning model, we implement an optical HE staining strategy based on subcellular morpho-spectral fingerprinting. |
| title | Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution |
| topic | Optics Image and Video Processing Biological Physics |
| url | https://arxiv.org/abs/2601.16904 |