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Main Authors: Filice, Francesca, De Rose, Edoardo, Bartucci, Simone, Calimeri, Francesco, Perri, Simona
Format: Preprint
Published: 2026
Subjects:
Online Access:https://arxiv.org/abs/2601.21830
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author Filice, Francesca
De Rose, Edoardo
Bartucci, Simone
Calimeri, Francesco
Perri, Simona
author_facet Filice, Francesca
De Rose, Edoardo
Bartucci, Simone
Calimeri, Francesco
Perri, Simona
contents The electrocardiogram (ECG) is a cost-effective, highly accessible and widely employed diagnostic tool. With the advent of Foundation Models (FMs), the field of AI-assisted ECG interpretation has begun to evolve, as they enable model reuse across different tasks by relying on embeddings. However, to responsibly employ FMs, it is crucial to rigorously assess to which extent the embeddings they produce are generalizable, particularly in error-sensitive domains such as healthcare. Although prior works have already addressed the problem of benchmarking ECG-expert FMs, they focus predominantly on the evaluation of downstream performance. To fill this gap, this study aims to find an in-depth, comprehensive benchmarking framework for FMs, with a specific focus on ECG-expert ones. To this aim, we introduce a benchmark methodology that complements performance-based evaluation with representation-level analysis, leveraging SHAP and UMAP techniques. Furthermore, we rely on the methodology for carrying out an extensive evaluation of several ECG-expert FMs pretrained via state-of-the-art techniques over different cross-continental datasets and data availability settings; this includes ones featuring data scarcity, a fairly common situation in real-world medical scenarios. Experimental results show that our benchmarking protocol provides a rich insight of ECG-expert FMs' embedded patterns, enabling a deeper understanding of their representational structure and generalizability.
format Preprint
id arxiv_https___arxiv_org_abs_2601_21830
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Looking Beyond Accuracy: A Holistic Benchmark of ECG Foundation Models
Filice, Francesca
De Rose, Edoardo
Bartucci, Simone
Calimeri, Francesco
Perri, Simona
Artificial Intelligence
The electrocardiogram (ECG) is a cost-effective, highly accessible and widely employed diagnostic tool. With the advent of Foundation Models (FMs), the field of AI-assisted ECG interpretation has begun to evolve, as they enable model reuse across different tasks by relying on embeddings. However, to responsibly employ FMs, it is crucial to rigorously assess to which extent the embeddings they produce are generalizable, particularly in error-sensitive domains such as healthcare. Although prior works have already addressed the problem of benchmarking ECG-expert FMs, they focus predominantly on the evaluation of downstream performance. To fill this gap, this study aims to find an in-depth, comprehensive benchmarking framework for FMs, with a specific focus on ECG-expert ones. To this aim, we introduce a benchmark methodology that complements performance-based evaluation with representation-level analysis, leveraging SHAP and UMAP techniques. Furthermore, we rely on the methodology for carrying out an extensive evaluation of several ECG-expert FMs pretrained via state-of-the-art techniques over different cross-continental datasets and data availability settings; this includes ones featuring data scarcity, a fairly common situation in real-world medical scenarios. Experimental results show that our benchmarking protocol provides a rich insight of ECG-expert FMs' embedded patterns, enabling a deeper understanding of their representational structure and generalizability.
title Looking Beyond Accuracy: A Holistic Benchmark of ECG Foundation Models
topic Artificial Intelligence
url https://arxiv.org/abs/2601.21830