Radiomics in Medical Imaging: Methods, Applications, and Challenges

Fuente: arXiv
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Autores principales: Neha, Fnu, Shukla, Deepak kumar
Formato: Preprint
Publicado: 2026
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author Neha, Fnu
Shukla, Deepak kumar
author_facet Neha, Fnu
Shukla, Deepak kumar
contents Radiomics enables quantitative medical image analysis by converting imaging data into structured, high-dimensional feature representations for predictive modeling. Despite methodological developments and encouraging retrospective results, radiomics continue to face persistent challenges related to feature instability, limited reproducibility, validation bias, and restricted clinical translation. Existing reviews largely focus on application-specific outcomes or isolated pipeline components, with limited analysis of how interdependent design choices across acquisition, preprocessing, feature engineering, modeling, and evaluation collectively affect robustness and generalizability. This survey provides an end-to-end analysis of radiomics pipelines, examining how methodological decisions at each stage influence feature stability, model reliability, and translational validity. This paper reviews radiomic feature extraction, selection, and dimensionality reduction strategies; classical machine and deep learning-based modeling approaches; and ensemble and hybrid frameworks, with emphasis on validation protocols, data leakage prevention, and statistical reliability. Clinical applications are discussed with a focus on evaluation rigor rather than reported performance metrics. The survey identifies open challenges in standardization, domain shift, and clinical deployment, and outlines future directions such as hybrid radiomics-artificial intelligence models, multimodal fusion, federated learning, and standardized benchmarking.
format Preprint
id arxiv_https___arxiv_org_abs_2602_00102
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publishDate 2026
record_format arxiv
spellingShingle Radiomics in Medical Imaging: Methods, Applications, and Challenges
Neha, Fnu
Shukla, Deepak kumar
Image and Video Processing
Artificial Intelligence
Machine Learning
Radiomics enables quantitative medical image analysis by converting imaging data into structured, high-dimensional feature representations for predictive modeling. Despite methodological developments and encouraging retrospective results, radiomics continue to face persistent challenges related to feature instability, limited reproducibility, validation bias, and restricted clinical translation. Existing reviews largely focus on application-specific outcomes or isolated pipeline components, with limited analysis of how interdependent design choices across acquisition, preprocessing, feature engineering, modeling, and evaluation collectively affect robustness and generalizability. This survey provides an end-to-end analysis of radiomics pipelines, examining how methodological decisions at each stage influence feature stability, model reliability, and translational validity. This paper reviews radiomic feature extraction, selection, and dimensionality reduction strategies; classical machine and deep learning-based modeling approaches; and ensemble and hybrid frameworks, with emphasis on validation protocols, data leakage prevention, and statistical reliability. Clinical applications are discussed with a focus on evaluation rigor rather than reported performance metrics. The survey identifies open challenges in standardization, domain shift, and clinical deployment, and outlines future directions such as hybrid radiomics-artificial intelligence models, multimodal fusion, federated learning, and standardized benchmarking.
title Radiomics in Medical Imaging: Methods, Applications, and Challenges
topic Image and Video Processing
Artificial Intelligence
Machine Learning
url https://arxiv.org/abs/2602.00102