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| Autori principali: | , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2026
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| Soggetti: | |
| Accesso online: | https://arxiv.org/abs/2602.00137 |
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| _version_ | 1866910241764933632 |
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| author | Torabi, Corinna Suzuki, Takayuki Helm, Emily Khoo, Harrison Tanenbaum, Sophie Schulman, Rebecca Hur, Soojung Claire |
| author_facet | Torabi, Corinna Suzuki, Takayuki Helm, Emily Khoo, Harrison Tanenbaum, Sophie Schulman, Rebecca Hur, Soojung Claire |
| contents | Stimulus-responsive DNA-hydrogels with swelling capabilities are a promising class of materials for biomedical applications such as drug delivery and biosensing. However, translation of these systems to microscale applications requires fabrication methods that are both biocompatible and material-efficient, while enabling precise control over stimulus-induced swelling and its impact on molecular transport. Here, we present a biocompatible fabrication and characterization platform for micron-scale DNA-hydrogels (microSDs) with tunable isotropic swelling and dissolving properties. Our approach includes a biocompatible, material-efficient fabrication workflow that conserves valuable DNA reagents by minimizing dead volume and process loss. We then demonstrated modular control over isotropic swelling in microSDs, achieving up to a two-fold size increase through programmable DNA design parameters. We further established a quantitative workflow to extract effective diffusivity and characterize swelling-induced modulation of molecular transport in spherical microSDs using YOYO-1. Finally, we demonstrate the dissolution of microSDs using a DNA strand and find that dissolution kinetics are governed by the rates of coupled strand-displacement reactions and diffusive transport. This platform enables programmable swelling and structural disassembly in microSDs. Swelling-induced network expansion further allows predictable modulation of molecular transport, thereby expanding the potential of microSDs for applications such as triggered drug delivery, multiplexed biosensing, and single-cell assays. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_00137 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Biocompatible Microscale DNA Hydrogels with Programmable Swelling and Sequence-Specific Dissolution Torabi, Corinna Suzuki, Takayuki Helm, Emily Khoo, Harrison Tanenbaum, Sophie Schulman, Rebecca Hur, Soojung Claire Soft Condensed Matter Stimulus-responsive DNA-hydrogels with swelling capabilities are a promising class of materials for biomedical applications such as drug delivery and biosensing. However, translation of these systems to microscale applications requires fabrication methods that are both biocompatible and material-efficient, while enabling precise control over stimulus-induced swelling and its impact on molecular transport. Here, we present a biocompatible fabrication and characterization platform for micron-scale DNA-hydrogels (microSDs) with tunable isotropic swelling and dissolving properties. Our approach includes a biocompatible, material-efficient fabrication workflow that conserves valuable DNA reagents by minimizing dead volume and process loss. We then demonstrated modular control over isotropic swelling in microSDs, achieving up to a two-fold size increase through programmable DNA design parameters. We further established a quantitative workflow to extract effective diffusivity and characterize swelling-induced modulation of molecular transport in spherical microSDs using YOYO-1. Finally, we demonstrate the dissolution of microSDs using a DNA strand and find that dissolution kinetics are governed by the rates of coupled strand-displacement reactions and diffusive transport. This platform enables programmable swelling and structural disassembly in microSDs. Swelling-induced network expansion further allows predictable modulation of molecular transport, thereby expanding the potential of microSDs for applications such as triggered drug delivery, multiplexed biosensing, and single-cell assays. |
| title | Biocompatible Microscale DNA Hydrogels with Programmable Swelling and Sequence-Specific Dissolution |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2602.00137 |