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Autori principali: Alagha, Ahmed, Leclerc, Christopher, Kotp, Yousef, Metwally, Omar, Moras, Calvin, Rentopoulos, Peter, Rostami, Ghodsiyeh, Nguyen, Bich Ngoc, Baig, Jumanah, Khellaf, Abdelhakim, Trinh, Vincent Quoc-Huy, Mizouni, Rabeb, Otrok, Hadi, Bentahar, Jamal, Hosseini, Mahdi S.
Natura: Preprint
Pubblicazione: 2026
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Accesso online:https://arxiv.org/abs/2602.03998
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author Alagha, Ahmed
Leclerc, Christopher
Kotp, Yousef
Metwally, Omar
Moras, Calvin
Rentopoulos, Peter
Rostami, Ghodsiyeh
Nguyen, Bich Ngoc
Baig, Jumanah
Khellaf, Abdelhakim
Trinh, Vincent Quoc-Huy
Mizouni, Rabeb
Otrok, Hadi
Bentahar, Jamal
Hosseini, Mahdi S.
author_facet Alagha, Ahmed
Leclerc, Christopher
Kotp, Yousef
Metwally, Omar
Moras, Calvin
Rentopoulos, Peter
Rostami, Ghodsiyeh
Nguyen, Bich Ngoc
Baig, Jumanah
Khellaf, Abdelhakim
Trinh, Vincent Quoc-Huy
Mizouni, Rabeb
Otrok, Hadi
Bentahar, Jamal
Hosseini, Mahdi S.
contents Whole-slide image (WSI) preprocessing, comprising tissue detection followed by patch extraction, is foundational to AI-driven computational pathology but remains a major bottleneck for scaling to large and heterogeneous cohorts. We present AtlasPatch, a scalable framework that couples foundation-model tissue detection with high-throughput patch extraction at minimal computational overhead. Our tissue detector achieves high precision (0.986) and remains robust across varying tissue conditions (e.g., brightness, fragmentation, boundary definition, tissue heterogeneity) and common artifacts (e.g., pen/ink markings, scanner streaks). This robustness is enabled by our annotated, heterogeneous multi-cohort training set of ~30,000 WSI thumbnails combined with efficient adaptation of the Segment-Anything (SAM) model. AtlasPatch also reduces end-to-end WSI preprocessing time by up to 16$\times$ versus widely used deep-learning pipelines, without degrading downstream task performance. The AtlasPatch tool is open-source, efficiently parallelized for practical deployment, and supports options to save extracted patches or stream them into common feature-extraction models for on-the-fly embedding, making it adaptable to both pathology departments (tissue detection and quality control) and AI researchers (dataset creation and model training). AtlasPatch software package is available at https://github.com/AtlasAnalyticsLab/AtlasPatch.
format Preprint
id arxiv_https___arxiv_org_abs_2602_03998
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle AtlasPatch: Efficient Tissue Detection and High-throughput Patch Extraction for Computational Pathology at Scale
Alagha, Ahmed
Leclerc, Christopher
Kotp, Yousef
Metwally, Omar
Moras, Calvin
Rentopoulos, Peter
Rostami, Ghodsiyeh
Nguyen, Bich Ngoc
Baig, Jumanah
Khellaf, Abdelhakim
Trinh, Vincent Quoc-Huy
Mizouni, Rabeb
Otrok, Hadi
Bentahar, Jamal
Hosseini, Mahdi S.
Image and Video Processing
Computer Vision and Pattern Recognition
Quantitative Methods
Whole-slide image (WSI) preprocessing, comprising tissue detection followed by patch extraction, is foundational to AI-driven computational pathology but remains a major bottleneck for scaling to large and heterogeneous cohorts. We present AtlasPatch, a scalable framework that couples foundation-model tissue detection with high-throughput patch extraction at minimal computational overhead. Our tissue detector achieves high precision (0.986) and remains robust across varying tissue conditions (e.g., brightness, fragmentation, boundary definition, tissue heterogeneity) and common artifacts (e.g., pen/ink markings, scanner streaks). This robustness is enabled by our annotated, heterogeneous multi-cohort training set of ~30,000 WSI thumbnails combined with efficient adaptation of the Segment-Anything (SAM) model. AtlasPatch also reduces end-to-end WSI preprocessing time by up to 16$\times$ versus widely used deep-learning pipelines, without degrading downstream task performance. The AtlasPatch tool is open-source, efficiently parallelized for practical deployment, and supports options to save extracted patches or stream them into common feature-extraction models for on-the-fly embedding, making it adaptable to both pathology departments (tissue detection and quality control) and AI researchers (dataset creation and model training). AtlasPatch software package is available at https://github.com/AtlasAnalyticsLab/AtlasPatch.
title AtlasPatch: Efficient Tissue Detection and High-throughput Patch Extraction for Computational Pathology at Scale
topic Image and Video Processing
Computer Vision and Pattern Recognition
Quantitative Methods
url https://arxiv.org/abs/2602.03998