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Main Authors: Zhou, Junting, Chen, Jin, Hao, Linfeng, Cao, Denghui, Wang, Zheyu, Chen, Qiguang, Fu, Chaoyou, Chen, Jiaze, Wu, Yuchen, Zhang, Ge, Wang, Mingxuan, Huang, Wenhao, Yang, Tong
Format: Preprint
Published: 2026
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Online Access:https://arxiv.org/abs/2602.05857
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author Zhou, Junting
Chen, Jin
Hao, Linfeng
Cao, Denghui
Wang, Zheyu
Chen, Qiguang
Fu, Chaoyou
Chen, Jiaze
Wu, Yuchen
Zhang, Ge
Wang, Mingxuan
Huang, Wenhao
Yang, Tong
author_facet Zhou, Junting
Chen, Jin
Hao, Linfeng
Cao, Denghui
Wang, Zheyu
Chen, Qiguang
Fu, Chaoyou
Chen, Jiaze
Wu, Yuchen
Zhang, Ge
Wang, Mingxuan
Huang, Wenhao
Yang, Tong
contents The rapid evolution of large language models (LLMs) has expanded their capabilities from basic dialogue to advanced scientific reasoning. However, existing benchmarks in biology often fail to assess a critical skill required of researchers: the ability to integrate experimental results with contextual knowledge to derive meaningful conclusions. To address this gap, we introduce BABE(Biology Arena BEnchmark), a comprehensive benchmark designed to evaluate the experimental reasoning capabilities of biological AI systems. BABE is uniquely constructed from peer-reviewed research papers and real-world biological studies, ensuring that tasks reflect the complexity and interdisciplinary nature of actual scientific inquiry. BABE challenges models to perform causal reasoning and cross-scale inference. Our benchmark provides a robust framework for assessing how well AI systems can reason like practicing scientists, offering a more authentic measure of their potential to contribute to biological research.
format Preprint
id arxiv_https___arxiv_org_abs_2602_05857
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle BABE: Biology Arena BEnchmark
Zhou, Junting
Chen, Jin
Hao, Linfeng
Cao, Denghui
Wang, Zheyu
Chen, Qiguang
Fu, Chaoyou
Chen, Jiaze
Wu, Yuchen
Zhang, Ge
Wang, Mingxuan
Huang, Wenhao
Yang, Tong
Artificial Intelligence
The rapid evolution of large language models (LLMs) has expanded their capabilities from basic dialogue to advanced scientific reasoning. However, existing benchmarks in biology often fail to assess a critical skill required of researchers: the ability to integrate experimental results with contextual knowledge to derive meaningful conclusions. To address this gap, we introduce BABE(Biology Arena BEnchmark), a comprehensive benchmark designed to evaluate the experimental reasoning capabilities of biological AI systems. BABE is uniquely constructed from peer-reviewed research papers and real-world biological studies, ensuring that tasks reflect the complexity and interdisciplinary nature of actual scientific inquiry. BABE challenges models to perform causal reasoning and cross-scale inference. Our benchmark provides a robust framework for assessing how well AI systems can reason like practicing scientists, offering a more authentic measure of their potential to contribute to biological research.
title BABE: Biology Arena BEnchmark
topic Artificial Intelligence
url https://arxiv.org/abs/2602.05857