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Main Authors: Balderrama, Rocio, Dussel, Ignacio Ceresa, de la Vega, Constanza Sanchez
Format: Preprint
Published: 2026
Subjects:
Online Access:https://arxiv.org/abs/2602.06178
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author Balderrama, Rocio
Dussel, Ignacio Ceresa
de la Vega, Constanza Sanchez
author_facet Balderrama, Rocio
Dussel, Ignacio Ceresa
de la Vega, Constanza Sanchez
contents In this work we present a mathematical model that integrates the epidemiological dynamics of a vector-borne disease (SIR-SI) with Lotka Volterra predator prey ecological interactions. The study analyzes how the presence of natural predators acts as a biological control mechanism to regulate the vector population and, consequently, disease transmission in host. We introduce the concept of the ecological reproduction number, a threshold that links the amplitude of predator prey cycles to disease persistence, showing that natural control depends critically on the ratio between the maximum vector density and the minimum predator density. In scenarios where natural control is insufficient, we formulate an optimal control problem based on the release of predators. Using the Pontryagin Maximum Principle, we characterize the optimal strategy that minimizes the cumulative number of infected individuals and intervention costs, while simultaneously maximizing the susceptible host population at the end of the time horizon. Numerical simulations validate the effectiveness of the model, showing that external intervention mitigates the epidemic peak and stabilizes the system against the natural oscillations of biological populations.
format Preprint
id arxiv_https___arxiv_org_abs_2602_06178
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Optimal Control Strategies for Epidemic Dynamics: Integrating SIR-SI and Lotka--Volterra Models
Balderrama, Rocio
Dussel, Ignacio Ceresa
de la Vega, Constanza Sanchez
Optimization and Control
In this work we present a mathematical model that integrates the epidemiological dynamics of a vector-borne disease (SIR-SI) with Lotka Volterra predator prey ecological interactions. The study analyzes how the presence of natural predators acts as a biological control mechanism to regulate the vector population and, consequently, disease transmission in host. We introduce the concept of the ecological reproduction number, a threshold that links the amplitude of predator prey cycles to disease persistence, showing that natural control depends critically on the ratio between the maximum vector density and the minimum predator density. In scenarios where natural control is insufficient, we formulate an optimal control problem based on the release of predators. Using the Pontryagin Maximum Principle, we characterize the optimal strategy that minimizes the cumulative number of infected individuals and intervention costs, while simultaneously maximizing the susceptible host population at the end of the time horizon. Numerical simulations validate the effectiveness of the model, showing that external intervention mitigates the epidemic peak and stabilizes the system against the natural oscillations of biological populations.
title Optimal Control Strategies for Epidemic Dynamics: Integrating SIR-SI and Lotka--Volterra Models
topic Optimization and Control
url https://arxiv.org/abs/2602.06178