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First ex-vivo positronium imaging of tissues with modular J-PET scanner using $^{44}$Sc radionuclide

Fuente: arXiv

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Détails bibliographiques
Auteurs principaux:	Kubat, Karol, Das, Manish, Sharma, Sushil, Beyene, Ermias Y., Bilewicz, Aleksander, Choiński, Jarosław, Chug, Neha, Curceanu, Catalina, Czerwiński, Eryk, Hajduga, Jakub, Jalali, Sharareh, Kacprzak, Krzysztof, Kaplanoglu, Tevfik, Kapłon, Łukasz, Kasperska, Kamila, Khreptak, Aleksander, Korcyl, Grzegorz, Kozik, Tomasz, Kumar, Deepak, Kundu, Sumit Kumar, Kunimmal-Venadan, Anoop, Leszczyński, Bartosz, Lisowski, Edward, Lisowski, Filip, Mędrala-Sowa, Justyna, Moyo, Simbarashe, Mryka, Wiktor, Niedźwiecki, Szymon, Pandey, Anand, Pandey, Piyush, Parzych, Szymon, Porcelli, Alessio, Rachwał, Bartłomiej, Rädler, Martin, Skurzok, Magdalena, Stolarz, Anna, Szumlak, Tomasz, Tanty, Pooja, Ardebili, Keyvan Tayefi, Tiwari, Satyam, Eliyan, Kavya Valsan, Walczak, Rafał, Moskal, Paweł, Stępień, Ewa Ł.
Format:	Preprint
Publié:	2026
Sujets:	Medical Physics
Accès en ligne:	Acceder al recurso
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_version_	1866914314079698944
author	Kubat, Karol Das, Manish Sharma, Sushil Beyene, Ermias Y. Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kumar, Deepak Kundu, Sumit Kumar Kunimmal-Venadan, Anoop Leszczyński, Bartosz Lisowski, Edward Lisowski, Filip Mędrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Anand Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej Rädler, Martin Skurzok, Magdalena Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Moskal, Paweł Stępień, Ewa Ł.
author_facet	Kubat, Karol Das, Manish Sharma, Sushil Beyene, Ermias Y. Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kumar, Deepak Kundu, Sumit Kumar Kunimmal-Venadan, Anoop Leszczyński, Bartosz Lisowski, Edward Lisowski, Filip Mędrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Anand Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej Rädler, Martin Skurzok, Magdalena Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Moskal, Paweł Stępień, Ewa Ł.
contents	This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the $^{44}$Sc radionuclide. The $^{44}$Sc isotope was produced via the $^{44}$Ca(p, n)$^{44}$Sc nuclear reaction and used to perform positronium imaging of phantom composed of human adipose tissue, cardiac myxoma tissue, thrombi blood clot, and also porous polymer XAD4, and a certified reference material (CRM) made from fused silica. The experiment demonstrates the suitability of $^{44}$Sc as a positron source for positronium imaging. The performance of J-PET for positronium imaging with $^{44}$Sc was validated by proper reconstruction of the mean orthopositronium lifetime for CRM material and XAD-4 polymer. The mean ortho-positronium (oPs) lifetimes determined for adipose tissue, cardiac myxoma tissues and thrombi were consistent with results of previous experiments. The study highlights the potential $^{44}$Sc radionuclide for positronium lifetime imaging (PLI).
format	Preprint
id	arxiv_https___arxiv_org_abs_2602_07580
institution	arXiv
publishDate	2026
record_format	arxiv
spellingShingle	First ex-vivo positronium imaging of tissues with modular J-PET scanner using $^{44}$Sc radionuclide Kubat, Karol Das, Manish Sharma, Sushil Beyene, Ermias Y. Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kumar, Deepak Kundu, Sumit Kumar Kunimmal-Venadan, Anoop Leszczyński, Bartosz Lisowski, Edward Lisowski, Filip Mędrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Anand Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej Rädler, Martin Skurzok, Magdalena Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Moskal, Paweł Stępień, Ewa Ł. Medical Physics This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the $^{44}$Sc radionuclide. The $^{44}$Sc isotope was produced via the $^{44}$Ca(p, n)$^{44}$Sc nuclear reaction and used to perform positronium imaging of phantom composed of human adipose tissue, cardiac myxoma tissue, thrombi blood clot, and also porous polymer XAD4, and a certified reference material (CRM) made from fused silica. The experiment demonstrates the suitability of $^{44}$Sc as a positron source for positronium imaging. The performance of J-PET for positronium imaging with $^{44}$Sc was validated by proper reconstruction of the mean orthopositronium lifetime for CRM material and XAD-4 polymer. The mean ortho-positronium (oPs) lifetimes determined for adipose tissue, cardiac myxoma tissues and thrombi were consistent with results of previous experiments. The study highlights the potential $^{44}$Sc radionuclide for positronium lifetime imaging (PLI).
title	First ex-vivo positronium imaging of tissues with modular J-PET scanner using $^{44}$Sc radionuclide
topic	Medical Physics
url	https://arxiv.org/abs/2602.07580