Out-of-equilibrium selection pressure enhances inference from protein sequence data
Fuente:
arXiv
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2026
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866914324063191040 |
|---|---|
| author | Dietler, Nicola Malbranke, Cyril Bitbol, Anne-Florence |
| author_facet | Dietler, Nicola Malbranke, Cyril Bitbol, Anne-Florence |
| contents | Homologous proteins have similar three-dimensional structures and biological functions that shape their sequences. The resulting coevolution-driven correlations underlie methods from Potts models to AlphaFold, which infer protein structure and function from sequences. Using a minimal model, we show that fluctuating selection strength and the onset of new selection pressures improve coevolution-based inference of structural contacts. Our conclusions extend to realistic synthetic data and to the inference of interaction partners. Out-of-equilibrium noise arising from ubiquitous variations in natural selection thus enhances, rather than hinders, the success of inference from protein sequences. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_11427 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Out-of-equilibrium selection pressure enhances inference from protein sequence data Dietler, Nicola Malbranke, Cyril Bitbol, Anne-Florence Biomolecules Homologous proteins have similar three-dimensional structures and biological functions that shape their sequences. The resulting coevolution-driven correlations underlie methods from Potts models to AlphaFold, which infer protein structure and function from sequences. Using a minimal model, we show that fluctuating selection strength and the onset of new selection pressures improve coevolution-based inference of structural contacts. Our conclusions extend to realistic synthetic data and to the inference of interaction partners. Out-of-equilibrium noise arising from ubiquitous variations in natural selection thus enhances, rather than hinders, the success of inference from protein sequences. |
| title | Out-of-equilibrium selection pressure enhances inference from protein sequence data |
| topic | Biomolecules |
| url | https://arxiv.org/abs/2602.11427 |