Enregistré dans:
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Preprint |
| Publié: |
2026
|
| Sujets: | |
| Accès en ligne: | https://arxiv.org/abs/2602.11703 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1866908829477765120 |
|---|---|
| author | Xu, Qiwen Rügamer, David Wenz, Holger Fontana, Johann Meggyeshazi, Nora Bender, Andreas Maros, Máté E. |
| author_facet | Xu, Qiwen Rügamer, David Wenz, Holger Fontana, Johann Meggyeshazi, Nora Bender, Andreas Maros, Máté E. |
| contents | Digital subtraction angiography (DSA) plays a central role in the diagnosis and treatment of cerebrovascular disease, yet its invasive nature and high acquisition cost severely limit large-scale data collection and public data sharing. Therefore, we developed a semantically conditioned latent diffusion model (LDM) that synthesizes arterial-phase cerebral DSA frames under explicit control of anatomical circulation (anterior vs.\ posterior) and canonical C-arm positions. We curated a large single-centre DSA dataset of 99,349 frames and trained a conditional LDM using text embeddings that encoded anatomy and acquisition geometry. To assess clinical realism, four medical experts, including two neuroradiologists, one neurosurgeon, and one internal medicine expert, systematically rated 400 synthetic DSA images using a 5-grade Likert scale for evaluating proximal large, medium, and small peripheral vessels. The generated images achieved image-wise overall Likert scores ranging from 3.1 to 3.3, with high inter-rater reliability (ICC(2,k) = 0.80--0.87). Distributional similarity to real DSA frames was supported by a low median Fréchet inception distance (FID) of 15.27. Our results indicate that semantically controlled LDMs can produce realistic synthetic DSAs suitable for downstream algorithm development, research, and training. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_11703 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Semantically Conditioned Diffusion Models for Cerebral DSA Synthesis Xu, Qiwen Rügamer, David Wenz, Holger Fontana, Johann Meggyeshazi, Nora Bender, Andreas Maros, Máté E. Computer Vision and Pattern Recognition Artificial Intelligence Digital subtraction angiography (DSA) plays a central role in the diagnosis and treatment of cerebrovascular disease, yet its invasive nature and high acquisition cost severely limit large-scale data collection and public data sharing. Therefore, we developed a semantically conditioned latent diffusion model (LDM) that synthesizes arterial-phase cerebral DSA frames under explicit control of anatomical circulation (anterior vs.\ posterior) and canonical C-arm positions. We curated a large single-centre DSA dataset of 99,349 frames and trained a conditional LDM using text embeddings that encoded anatomy and acquisition geometry. To assess clinical realism, four medical experts, including two neuroradiologists, one neurosurgeon, and one internal medicine expert, systematically rated 400 synthetic DSA images using a 5-grade Likert scale for evaluating proximal large, medium, and small peripheral vessels. The generated images achieved image-wise overall Likert scores ranging from 3.1 to 3.3, with high inter-rater reliability (ICC(2,k) = 0.80--0.87). Distributional similarity to real DSA frames was supported by a low median Fréchet inception distance (FID) of 15.27. Our results indicate that semantically controlled LDMs can produce realistic synthetic DSAs suitable for downstream algorithm development, research, and training. |
| title | Semantically Conditioned Diffusion Models for Cerebral DSA Synthesis |
| topic | Computer Vision and Pattern Recognition Artificial Intelligence |
| url | https://arxiv.org/abs/2602.11703 |