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| Main Authors: | , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2602.15442 |
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| _version_ | 1866917277870325760 |
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| author | Čoko, Urban Potisk, Tilen Praprotnik, Matej |
| author_facet | Čoko, Urban Potisk, Tilen Praprotnik, Matej |
| contents | Ultrasound-matter interactions underpin numerous biomedical and soft-matter applications, yet simulating these phenomena is challenging due to the large separation of viscous and sonic time scales. Continuum methods capture large-scale wave propagation but cannot resolve microscale interactions, while particle-based approaches offer molecular resolution but struggle with efficiency and stability at larger scales. We introduce a particle-based virtual ultrasound machine that uses a novel smoothed dissipative particle dynamics variant with an implicit pressure solver and a negative-pressure stabilization scheme, required to mimic acoustic propagation across MHz-GHz frequencies. We demonstrate its capabilities by modeling the acoustophoresis of encapsulated microbubbles, a key mechanism in ultrasound-mediated drug delivery. Beyond this application, the approach establishes a generalizable platform for simulating wave-matter interactions in soft and biological materials, opening new directions for computational studies of acoustics-driven phenomena in science and engineering. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_15442 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Virtual ultrasound machine operating in a GHz to MHz frequency range for particle-based biomedical simulations Čoko, Urban Potisk, Tilen Praprotnik, Matej Soft Condensed Matter Mesoscale and Nanoscale Physics Biological Physics Computational Physics Ultrasound-matter interactions underpin numerous biomedical and soft-matter applications, yet simulating these phenomena is challenging due to the large separation of viscous and sonic time scales. Continuum methods capture large-scale wave propagation but cannot resolve microscale interactions, while particle-based approaches offer molecular resolution but struggle with efficiency and stability at larger scales. We introduce a particle-based virtual ultrasound machine that uses a novel smoothed dissipative particle dynamics variant with an implicit pressure solver and a negative-pressure stabilization scheme, required to mimic acoustic propagation across MHz-GHz frequencies. We demonstrate its capabilities by modeling the acoustophoresis of encapsulated microbubbles, a key mechanism in ultrasound-mediated drug delivery. Beyond this application, the approach establishes a generalizable platform for simulating wave-matter interactions in soft and biological materials, opening new directions for computational studies of acoustics-driven phenomena in science and engineering. |
| title | Virtual ultrasound machine operating in a GHz to MHz frequency range for particle-based biomedical simulations |
| topic | Soft Condensed Matter Mesoscale and Nanoscale Physics Biological Physics Computational Physics |
| url | https://arxiv.org/abs/2602.15442 |