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Main Authors: Exler, David, Gómez, Joaquin Eduardo Urrutia, Krüger, Martin, Schliephake, Maike, Jbeily, John, Vitacolonna, Mario, Rudolf, Rüdiger, Reischl, Markus
Format: Preprint
Published: 2026
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Online Access:https://arxiv.org/abs/2602.15660
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author Exler, David
Gómez, Joaquin Eduardo Urrutia
Krüger, Martin
Schliephake, Maike
Jbeily, John
Vitacolonna, Mario
Rudolf, Rüdiger
Reischl, Markus
author_facet Exler, David
Gómez, Joaquin Eduardo Urrutia
Krüger, Martin
Schliephake, Maike
Jbeily, John
Vitacolonna, Mario
Rudolf, Rüdiger
Reischl, Markus
contents Deep learning-based segmentation and classification are crucial to large-scale biomedical imaging, particularly for 3D data, where manual analysis is impractical. Although many methods exist, selecting suitable models and tuning parameters remains a major bottleneck in practice. Hence, we introduce the 3D data Analysis Optimization Pipeline, a method designed to facilitate the design and parameterization of segmentation and classification using two Bayesian Optimization stages. First, the pipeline selects a segmentation model and optimizes postprocessing parameters using a domain-adapted syntactic benchmark dataset. To ensure a concise evaluation of segmentation performance, we introduce a segmentation quality metric that serves as the objective function. Second, the pipeline optimizes design choices of a classifier, such as encoder and classifier head architectures, incorporation of prior knowledge, and pretraining strategies. To reduce manual annotation effort, this stage includes an assisted class-annotation workflow that extracts predicted instances from the segmentation results and sequentially presents them to the operator, eliminating the need for manual tracking. In four case studies, the 3D data Analysis Optimization Pipeline efficiently identifies effective model and parameter configurations for individual datasets.
format Preprint
id arxiv_https___arxiv_org_abs_2602_15660
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Bayesian Optimization for Design Parameters of 3D Image Data Analysis
Exler, David
Gómez, Joaquin Eduardo Urrutia
Krüger, Martin
Schliephake, Maike
Jbeily, John
Vitacolonna, Mario
Rudolf, Rüdiger
Reischl, Markus
Computer Vision and Pattern Recognition
Artificial Intelligence
Deep learning-based segmentation and classification are crucial to large-scale biomedical imaging, particularly for 3D data, where manual analysis is impractical. Although many methods exist, selecting suitable models and tuning parameters remains a major bottleneck in practice. Hence, we introduce the 3D data Analysis Optimization Pipeline, a method designed to facilitate the design and parameterization of segmentation and classification using two Bayesian Optimization stages. First, the pipeline selects a segmentation model and optimizes postprocessing parameters using a domain-adapted syntactic benchmark dataset. To ensure a concise evaluation of segmentation performance, we introduce a segmentation quality metric that serves as the objective function. Second, the pipeline optimizes design choices of a classifier, such as encoder and classifier head architectures, incorporation of prior knowledge, and pretraining strategies. To reduce manual annotation effort, this stage includes an assisted class-annotation workflow that extracts predicted instances from the segmentation results and sequentially presents them to the operator, eliminating the need for manual tracking. In four case studies, the 3D data Analysis Optimization Pipeline efficiently identifies effective model and parameter configurations for individual datasets.
title Bayesian Optimization for Design Parameters of 3D Image Data Analysis
topic Computer Vision and Pattern Recognition
Artificial Intelligence
url https://arxiv.org/abs/2602.15660