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Main Authors: Hullman, Jessica, Broska, David, Sun, Huaman, Shaw, Aaron
Format: Preprint
Published: 2026
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Online Access:https://arxiv.org/abs/2602.15785
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author Hullman, Jessica
Broska, David
Sun, Huaman
Shaw, Aaron
author_facet Hullman, Jessica
Broska, David
Sun, Huaman
Shaw, Aaron
contents A growing literature uses large language models (LLMs) as synthetic participants to generate cost-effective and nearly instantaneous responses in social science experiments. However, there is limited guidance on when such simulations support valid inference about human behavior. We contrast two strategies for obtaining valid estimates of causal effects and clarify the assumptions under which each is suitable for exploratory versus confirmatory research. Heuristic approaches seek to establish that simulated and observed human behavior are interchangeable through prompt engineering, model fine-tuning, and other repair strategies designed to reduce LLM-induced inaccuracies. While useful for many exploratory tasks, heuristic approaches lack the formal statistical guarantees typically required for confirmatory research. In contrast, statistical calibration combines auxiliary human data with statistical adjustments to account for discrepancies between observed and simulated responses. Under explicit assumptions, statistical calibration preserves validity and provides more precise estimates of causal effects at lower cost than experiments that rely solely on human participants. Yet the potential of both approaches depends on how well LLMs approximate the relevant populations. We consider what opportunities are overlooked when researchers focus myopically on substituting LLMs for human participants in a study.
format Preprint
id arxiv_https___arxiv_org_abs_2602_15785
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle This human study did not involve human subjects: Validating LLM simulations as behavioral evidence
Hullman, Jessica
Broska, David
Sun, Huaman
Shaw, Aaron
Artificial Intelligence
A growing literature uses large language models (LLMs) as synthetic participants to generate cost-effective and nearly instantaneous responses in social science experiments. However, there is limited guidance on when such simulations support valid inference about human behavior. We contrast two strategies for obtaining valid estimates of causal effects and clarify the assumptions under which each is suitable for exploratory versus confirmatory research. Heuristic approaches seek to establish that simulated and observed human behavior are interchangeable through prompt engineering, model fine-tuning, and other repair strategies designed to reduce LLM-induced inaccuracies. While useful for many exploratory tasks, heuristic approaches lack the formal statistical guarantees typically required for confirmatory research. In contrast, statistical calibration combines auxiliary human data with statistical adjustments to account for discrepancies between observed and simulated responses. Under explicit assumptions, statistical calibration preserves validity and provides more precise estimates of causal effects at lower cost than experiments that rely solely on human participants. Yet the potential of both approaches depends on how well LLMs approximate the relevant populations. We consider what opportunities are overlooked when researchers focus myopically on substituting LLMs for human participants in a study.
title This human study did not involve human subjects: Validating LLM simulations as behavioral evidence
topic Artificial Intelligence
url https://arxiv.org/abs/2602.15785