Equal Marginal Power for Co-Primary Endpoints
Fuente:
arXiv
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| Autor principal: | |
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| Formato: | Preprint |
| Publicado: |
2026
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| Materias: | |
| Acceso en línea: | |
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| _version_ | 1866912915654705152 |
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| author | Bond, Simon |
| author_facet | Bond, Simon |
| contents | The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_18161 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Equal Marginal Power for Co-Primary Endpoints Bond, Simon Methodology The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics. |
| title | Equal Marginal Power for Co-Primary Endpoints |
| topic | Methodology |
| url | https://arxiv.org/abs/2602.18161 |