Toward a CMOS-integrated quantum diamond biosensor based on NV centers
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| Main Authors: | , , , , , , , , |
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| Format: | Preprint |
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2026
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| _version_ | 1866917290746839040 |
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| author | Varveris, Ioannis Aliberti, Gianni D. Barzilaij, Felix J. Jin, Zhi van Rijs, Samantha A. Dong, Qiangrui Brinks, Daan Nur, Salahuddin Ishihara, Ryoichi |
| author_facet | Varveris, Ioannis Aliberti, Gianni D. Barzilaij, Felix J. Jin, Zhi van Rijs, Samantha A. Dong, Qiangrui Brinks, Daan Nur, Salahuddin Ishihara, Ryoichi |
| contents | We report progress toward a CMOS-integrated quantum diamond biosensing platform that combines nitrogen-vacancy (NV) centers in diamond with a custom 40 nm CMOS Single-Photon Avalanche Diode (SPAD) array. The system integrates on-chip active quenching and digital readout with external FPGA-based photon counting, compact microwave delivery, and practical optical excitation and collection schemes to support widefield optically detected magnetic resonance (ODMR). System-level design considerations spanning fluorescence collection efficiency, detector count-rate capability, and microwave homogeneity are analyzed with biological compatibility and scalability in mind. Using superparamagnetic iron oxide nanoparticle (SPION)-labeled HEK293T cells as a representative use case, simple dipole-field estimates indicate that sub-$μ$T sensitivity is required to resolve ODMR shifts within typical ensemble linewidths. Based on the proposed architecture and efficiency analysis, a magnetic field sensitivity of approximately 90 nT/$\sqrt{\mathrm{Hz}}$ per pixel is estimated. These results outline a practical path from optics-heavy quantum diamond microscopes toward compact, CMOS-integrated NV-based biosensors for quantitative magnetic imaging in complex biological environments. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_20437 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Toward a CMOS-integrated quantum diamond biosensor based on NV centers Varveris, Ioannis Aliberti, Gianni D. Barzilaij, Felix J. Jin, Zhi van Rijs, Samantha A. Dong, Qiangrui Brinks, Daan Nur, Salahuddin Ishihara, Ryoichi Applied Physics Quantum Physics We report progress toward a CMOS-integrated quantum diamond biosensing platform that combines nitrogen-vacancy (NV) centers in diamond with a custom 40 nm CMOS Single-Photon Avalanche Diode (SPAD) array. The system integrates on-chip active quenching and digital readout with external FPGA-based photon counting, compact microwave delivery, and practical optical excitation and collection schemes to support widefield optically detected magnetic resonance (ODMR). System-level design considerations spanning fluorescence collection efficiency, detector count-rate capability, and microwave homogeneity are analyzed with biological compatibility and scalability in mind. Using superparamagnetic iron oxide nanoparticle (SPION)-labeled HEK293T cells as a representative use case, simple dipole-field estimates indicate that sub-$μ$T sensitivity is required to resolve ODMR shifts within typical ensemble linewidths. Based on the proposed architecture and efficiency analysis, a magnetic field sensitivity of approximately 90 nT/$\sqrt{\mathrm{Hz}}$ per pixel is estimated. These results outline a practical path from optics-heavy quantum diamond microscopes toward compact, CMOS-integrated NV-based biosensors for quantitative magnetic imaging in complex biological environments. |
| title | Toward a CMOS-integrated quantum diamond biosensor based on NV centers |
| topic | Applied Physics Quantum Physics |
| url | https://arxiv.org/abs/2602.20437 |