Lost in Projection? Gaussian Filtering Recovers Hidden Conformational States
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| Main Authors: | , , , |
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| Format: | Preprint |
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2026
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| _version_ | 1866917291880349696 |
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| author | Sartore, Sofia Nagel, Daniel Diez, Georg Stock, Gerhard |
| author_facet | Sartore, Sofia Nagel, Daniel Diez, Georg Stock, Gerhard |
| contents | To interpret molecular dynamics (MD) simulations, it is common practice to reduce the dimensionality of the molecular coordinates to a low-dimensional collective variable $x$. Projecting the high-dimensional MD data onto $x$ yields a free energy landscape $ΔG(x)$, which highlights low-energy regions corresponding to conformational states. The accurate definition of these states, however, is often impeded by projection artifacts, resulting in artificially shortened state lifetimes or even the complete disappearance of states from the analysis. As demonstrated for a two-dimensional toy model, Gaussian low-pass filtering of the high-dimensional MD coordinates can restore the underlying free energy landscape, allowing to recover previously hidden states. When applied to an all-atom folding trajectory of HP35, the number of microstates increases by an order of magnitude, which leads to metastable states that are long-lived and much better defined structurally, even compared to dynamically cored state trajectories. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2602_21006 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Lost in Projection? Gaussian Filtering Recovers Hidden Conformational States Sartore, Sofia Nagel, Daniel Diez, Georg Stock, Gerhard Soft Condensed Matter Biological Physics Computational Physics Data Analysis, Statistics and Probability To interpret molecular dynamics (MD) simulations, it is common practice to reduce the dimensionality of the molecular coordinates to a low-dimensional collective variable $x$. Projecting the high-dimensional MD data onto $x$ yields a free energy landscape $ΔG(x)$, which highlights low-energy regions corresponding to conformational states. The accurate definition of these states, however, is often impeded by projection artifacts, resulting in artificially shortened state lifetimes or even the complete disappearance of states from the analysis. As demonstrated for a two-dimensional toy model, Gaussian low-pass filtering of the high-dimensional MD coordinates can restore the underlying free energy landscape, allowing to recover previously hidden states. When applied to an all-atom folding trajectory of HP35, the number of microstates increases by an order of magnitude, which leads to metastable states that are long-lived and much better defined structurally, even compared to dynamically cored state trajectories. |
| title | Lost in Projection? Gaussian Filtering Recovers Hidden Conformational States |
| topic | Soft Condensed Matter Biological Physics Computational Physics Data Analysis, Statistics and Probability |
| url | https://arxiv.org/abs/2602.21006 |