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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2602.22228 |
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Table of Contents:
- Stroke affected millions annually, yet poor symptom recognition often delayed care-seeking. To address risk recognition gap, we developed a passive surveillance system for early stroke risk detection using patient-reported symptoms among individuals with diabetes. Constructing a symptom taxonomy grounded in patients own language and a dual machine learning pipeline (heterogeneous GNN and EN/LASSO), we identified symptom patterns associated with subsequent stroke. We translated findings into a hybrid risk screening system integrating symptom relevance and temporal proximity, evaluated across 3-90 day windows through EHR-based simulations. Under conservative thresholds, intentionally designed to minimize false alerts, the screening system achieved high specificity (1.00) and prevalence-adjusted positive predictive value (1.00), with good sensitivity (0.72), an expected trade-off prioritizing precision, that was highest in 90-day window. Patient-reported language alone supported high-precision, low-burden early stroke risk detection, that could offer a valuable time window for clinical evaluation and intervention for high-risk individuals.