Induction Meets Biology: Mechanisms of Repeat Detection in Protein Language Models
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
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2026
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| _version_ | 1866910275062464512 |
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| author | Pomerants, Gal Nikankin, Yaniv Reusch, Anja Tsaban, Tomer Schueler-Furman, Ora Belinkov, Yonatan |
| author_facet | Pomerants, Gal Nikankin, Yaniv Reusch, Anja Tsaban, Tomer Schueler-Furman, Ora Belinkov, Yonatan |
| contents | Protein sequences are abundant in repeating segments, both as exact copies and as approximate segments with mutations. These repeats are important for protein structure and function, motivating decades of algorithmic work on repeat identification. Recent work has shown that protein language models (PLMs) identify repeats, by examining their behavior in masked-token prediction. To elucidate their internal mechanisms, we investigate how PLMs detect both exact and approximate repeats. We find that the mechanism for approximate repeats functionally subsumes that of exact repeats. We then characterize this mechanism, revealing two main stages: PLMs first build feature representations using both general positional attention heads and biologically specialized components, such as neurons that encode amino-acid similarity. Then, induction heads attend to aligned tokens across repeated segments, promoting the correct answer. Our results reveal how PLMs solve this biological task by combining language-based pattern matching with specialized biological knowledge, thereby establishing a basis for studying more complex evolutionary processes in PLMs. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2602_23179 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Induction Meets Biology: Mechanisms of Repeat Detection in Protein Language Models Pomerants, Gal Nikankin, Yaniv Reusch, Anja Tsaban, Tomer Schueler-Furman, Ora Belinkov, Yonatan Machine Learning Biomolecules Protein sequences are abundant in repeating segments, both as exact copies and as approximate segments with mutations. These repeats are important for protein structure and function, motivating decades of algorithmic work on repeat identification. Recent work has shown that protein language models (PLMs) identify repeats, by examining their behavior in masked-token prediction. To elucidate their internal mechanisms, we investigate how PLMs detect both exact and approximate repeats. We find that the mechanism for approximate repeats functionally subsumes that of exact repeats. We then characterize this mechanism, revealing two main stages: PLMs first build feature representations using both general positional attention heads and biologically specialized components, such as neurons that encode amino-acid similarity. Then, induction heads attend to aligned tokens across repeated segments, promoting the correct answer. Our results reveal how PLMs solve this biological task by combining language-based pattern matching with specialized biological knowledge, thereby establishing a basis for studying more complex evolutionary processes in PLMs. |
| title | Induction Meets Biology: Mechanisms of Repeat Detection in Protein Language Models |
| topic | Machine Learning Biomolecules |
| url | https://arxiv.org/abs/2602.23179 |