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Main Authors: LaMaster, John T., Gudmundson, Aaron T., Abaei, Alireza, Alcicek, Seyma, Alvarado, Arturo, Andronesi, Ovidiu, Bell, Tiffany K., Bogner, Wolfgang, Bugler, Hanna, Craven, Alexander R, Cudalbu, Cristina, Davidson, Alma, Davies-Jenkins, Christopher W., Deelchand, Dinesh, Edden, Richard A. E., Esmaeili, Morteza, Fleischer, Candace C, Gad, Abdelrahman, Genovese, Guglielmo, Gurbani, Saumya, Harris, Ashley D., Henry, Pierre-Gilles, Igwe, Kay Chioma, Joy, Ajin, Julià-Sapé, Margarida, Kim, Hyeonjin, Kreis, Roland, Lam, Fan, Landheer, Karl, Lanz, Bernard, Lee, Chu-Yu, Ligneul, Clémence, Merkofer, Julian P., Miller, Jack J., Mosso, Jessie, Motyka, Stanislav, Mougel, Eloïse, Mullins, Paul G., Murali-Manohar, Saipavitra, Najac, Chloé, Nakajima, Shinichiro, Oeltzschner, Georg, Ozturk-Isik, Esin, Palombo, Marco, Pilatus, Ulrich, Platek, Justyna, Van Praagh, Emma, Qu, Xiaobo, Rizzo, Rudy, Rodgers, Christopher T., Rodriguez, Esau Poblador, Rodriguez, Yeison, Sammi, Manoj K, van de Sande, Dennis M. J., Sarma, Manoj Kumar, Saviola, Francesca, Schrantee, Anouk, Shamaei, Amirmohammad, Simicic, Dunja, Soher, Brian J, Sollmann, Nico, Song, Yulu, Stanley, Jeffrey A, Strasser, Bernhard, Susnjar, Antonia, Swanberg, Kelley M., Thomas, M. Albert, Tkáč, Ivan, Tu, Zhangren, Weiser, Paul J., Widmaier, Mark, Wilson, Martin, Wu, Christopher J., Xin, Lijing, Zöllner, Helge J., Özdemir, İpek, Group, MRS Synthetic Data Working, Kaiser, Antonia
Format: Preprint
Published: 2026
Subjects:
Medical Physics
Online Access:https://arxiv.org/abs/2602.23463
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Table of Contents:
  • The use of synthetic data has emerged as an essential tool in Magnetic Resonance Spectroscopy (MRS) research and applications, providing advantages for optimization of acquisition, software validation, deep learning applications, and enhanced reproducibility. Importantly, synthetic data addresses challenges of limited training data availability, particularly for clinical populations, and offers controlled solutions for investigating uncertainties and unexplained variance with in vivo data. This work provides a review and evaluation of current practices in the use and generation of synthetic data within the MRS field. Conducted by the MRS Synthetic Data Working Group under the Code & Data Sharing Committee of the MRS Study Group of the International Society for Magnetic Resonance in Medicine (ISMRM), this manuscript encompasses existing literature, supplemented by collective experience and in-house methodologies.

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