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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2602.24127 |
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| _version_ | 1866915823570911232 |
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| author | Cabrera, Javier Alemayehu, Berhanu Alemayehu, Demissie Weigle, Sofia |
| author_facet | Cabrera, Javier Alemayehu, Berhanu Alemayehu, Demissie Weigle, Sofia |
| contents | When it is not feasible to conduct randomized controlled trials (RCTs), the use of external control arms based on real-world data (RWD) may be a viable option. However, challenges arising from data heterogeneity must be addressed to ensure the reliability of trial results. We consider the use of Natural Hermite and propensity score indices to facilitate robust comparisons between RCTs and RWD studies. Illustrations are provided on the implementation and performance of the underlying algorithms using simulated data, as well as synthetic data from a clinical trial and RWD. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2602_24127 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Advancing Evidence Generation in Biomedical Research Using Natural Hermite and Propensity Score Indices: Applications to External Control Arms Cabrera, Javier Alemayehu, Berhanu Alemayehu, Demissie Weigle, Sofia Applications 62A G.3 When it is not feasible to conduct randomized controlled trials (RCTs), the use of external control arms based on real-world data (RWD) may be a viable option. However, challenges arising from data heterogeneity must be addressed to ensure the reliability of trial results. We consider the use of Natural Hermite and propensity score indices to facilitate robust comparisons between RCTs and RWD studies. Illustrations are provided on the implementation and performance of the underlying algorithms using simulated data, as well as synthetic data from a clinical trial and RWD. |
| title | Advancing Evidence Generation in Biomedical Research Using Natural Hermite and Propensity Score Indices: Applications to External Control Arms |
| topic | Applications 62A G.3 |
| url | https://arxiv.org/abs/2602.24127 |