The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction
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| Format: | Preprint |
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2026
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| author | Garrucho, Lidia Joshi, Smriti Kushibar, Kaisar Osuala, Richard Bobowicz, Maciej Bargalló, Xavier Jaruševičius, Paulius Geissler, Kai Schäfer, Raphael Alberb, Muhammad Xu, Tony Martel, Anne Sleiman, Daniel Awasthi, Navchetan Awwad, Hadeel Vilanova, Joan C. Martí, Robert Schouten, Daan Lee, Jeong Hoon Rusu, Mirabela Poeta, Eleonora Vargas, Luisa Pastor, Eliana Zuluaga, Maria A. Kächele, Jessica Bounias, Dimitrios Ertl, Alexandra Gwoździewicz, Katarzyna Cosaka, Maria-Laura Abo-Elhoda, Pasant M. Tantawy, Sara W. Sakrana, Shorouq S. Shawky-Abdelfatah, Norhan O. Abdo-Salem, Amr Muhammad Kozana, Androniki Divjak, Eugen Ivanac, Gordana Nikiforaki, Katerina Klontzas, Michail E. García-Dosdá, Rosa Gulsun-Akpinar, Meltem Lafcı, Oğuz Martín-Isla, Carlos Díaz, Oliver Igual, Laura Lekadir, Karim |
| author_facet | Garrucho, Lidia Joshi, Smriti Kushibar, Kaisar Osuala, Richard Bobowicz, Maciej Bargalló, Xavier Jaruševičius, Paulius Geissler, Kai Schäfer, Raphael Alberb, Muhammad Xu, Tony Martel, Anne Sleiman, Daniel Awasthi, Navchetan Awwad, Hadeel Vilanova, Joan C. Martí, Robert Schouten, Daan Lee, Jeong Hoon Rusu, Mirabela Poeta, Eleonora Vargas, Luisa Pastor, Eliana Zuluaga, Maria A. Kächele, Jessica Bounias, Dimitrios Ertl, Alexandra Gwoździewicz, Katarzyna Cosaka, Maria-Laura Abo-Elhoda, Pasant M. Tantawy, Sara W. Sakrana, Shorouq S. Shawky-Abdelfatah, Norhan O. Abdo-Salem, Amr Muhammad Kozana, Androniki Divjak, Eugen Ivanac, Gordana Nikiforaki, Katerina Klontzas, Michail E. García-Dosdá, Rosa Gulsun-Akpinar, Meltem Lafcı, Oğuz Martín-Isla, Carlos Díaz, Oliver Igual, Laura Lekadir, Karim |
| contents | Breast cancer is the most frequently diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality. Dynamic contrast-enhanced magnetic resonance imaging plays a central role in tumor characterization and treatment monitoring, particularly in patients receiving neoadjuvant chemotherapy. However, existing artificial intelligence models for breast magnetic resonance imaging are often developed using single-center data and evaluated using aggregate performance metrics, limiting their generalizability and obscuring potential performance disparities across demographic subgroups. The MAMA-MIA Challenge was designed to address these limitations by introducing a large-scale benchmark that jointly evaluates primary tumor segmentation and prediction of pathologic complete response using pre-treatment magnetic resonance imaging only. The training cohort comprised 1,506 patients from multiple institutions in the United States, while evaluation was conducted on an external test set of 574 patients from three independent European centers to assess cross-continental and cross-institutional generalization. A unified scoring framework combined predictive performance with subgroup consistency across age, menopausal status, and breast density. Twenty-six international teams participated in the final evaluation phase. Results demonstrate substantial performance variability under external testing and reveal trade-offs between overall accuracy and subgroup fairness. The challenge provides standardized datasets, evaluation protocols, and public resources to promote the development of robust and equitable artificial intelligence systems for breast cancer imaging. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_01250 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction Garrucho, Lidia Joshi, Smriti Kushibar, Kaisar Osuala, Richard Bobowicz, Maciej Bargalló, Xavier Jaruševičius, Paulius Geissler, Kai Schäfer, Raphael Alberb, Muhammad Xu, Tony Martel, Anne Sleiman, Daniel Awasthi, Navchetan Awwad, Hadeel Vilanova, Joan C. Martí, Robert Schouten, Daan Lee, Jeong Hoon Rusu, Mirabela Poeta, Eleonora Vargas, Luisa Pastor, Eliana Zuluaga, Maria A. Kächele, Jessica Bounias, Dimitrios Ertl, Alexandra Gwoździewicz, Katarzyna Cosaka, Maria-Laura Abo-Elhoda, Pasant M. Tantawy, Sara W. Sakrana, Shorouq S. Shawky-Abdelfatah, Norhan O. Abdo-Salem, Amr Muhammad Kozana, Androniki Divjak, Eugen Ivanac, Gordana Nikiforaki, Katerina Klontzas, Michail E. García-Dosdá, Rosa Gulsun-Akpinar, Meltem Lafcı, Oğuz Martín-Isla, Carlos Díaz, Oliver Igual, Laura Lekadir, Karim Computer Vision and Pattern Recognition Artificial Intelligence Breast cancer is the most frequently diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality. Dynamic contrast-enhanced magnetic resonance imaging plays a central role in tumor characterization and treatment monitoring, particularly in patients receiving neoadjuvant chemotherapy. However, existing artificial intelligence models for breast magnetic resonance imaging are often developed using single-center data and evaluated using aggregate performance metrics, limiting their generalizability and obscuring potential performance disparities across demographic subgroups. The MAMA-MIA Challenge was designed to address these limitations by introducing a large-scale benchmark that jointly evaluates primary tumor segmentation and prediction of pathologic complete response using pre-treatment magnetic resonance imaging only. The training cohort comprised 1,506 patients from multiple institutions in the United States, while evaluation was conducted on an external test set of 574 patients from three independent European centers to assess cross-continental and cross-institutional generalization. A unified scoring framework combined predictive performance with subgroup consistency across age, menopausal status, and breast density. Twenty-six international teams participated in the final evaluation phase. Results demonstrate substantial performance variability under external testing and reveal trade-offs between overall accuracy and subgroup fairness. The challenge provides standardized datasets, evaluation protocols, and public resources to promote the development of robust and equitable artificial intelligence systems for breast cancer imaging. |
| title | The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction |
| topic | Computer Vision and Pattern Recognition Artificial Intelligence |
| url | https://arxiv.org/abs/2603.01250 |