K-MaT: Knowledge-Anchored Manifold Transport for Cross-Modal Prompt Learning in Medical Imaging
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| Format: | Preprint |
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2026
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| author | Zeng, Jiajun Albarqouni, Shadi |
| author_facet | Zeng, Jiajun Albarqouni, Shadi |
| contents | Large-scale biomedical vision-language models (VLMs) adapted on high-end imaging (e.g., CT) often fail to transfer to frontline low-end modalities (e.g., radiography), collapsing into modality-specific shortcuts. We propose K-MaT (Knowledge-Anchored Manifold Transport), a prompt-learning framework that transfers decision structures to low-end modalities without requiring low-end training images. K-MaT factorizes prompts, anchors them to clinical text descriptions, and aligns the low-end prompt manifold to the visually-grounded high-end space using Fused Gromov-Wasserstein optimal transport. We evaluate K-MaT on four cross-modal benchmarks, including dermoscopy, mammography to ultrasound, and CT to chest X-ray. K-MaT achieves state-of-the-art results, improving the average harmonic mean of accuracy to 44.1% (from BiomedCoOp's 42.0%) and macro-F1 to 36.2%. Notably, on the challenging breast imaging task, it mitigates the catastrophic forgetting seen in standard methods like CoOp (which drops to 27.0% accuracy on the low-end), preserving robust performance across modalities. Aligning prompt manifolds via optimal transport provides a highly effective route for the zero-shot cross-modal deployment of medical VLMs. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2603_06340 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | K-MaT: Knowledge-Anchored Manifold Transport for Cross-Modal Prompt Learning in Medical Imaging Zeng, Jiajun Albarqouni, Shadi Computer Vision and Pattern Recognition Artificial Intelligence Large-scale biomedical vision-language models (VLMs) adapted on high-end imaging (e.g., CT) often fail to transfer to frontline low-end modalities (e.g., radiography), collapsing into modality-specific shortcuts. We propose K-MaT (Knowledge-Anchored Manifold Transport), a prompt-learning framework that transfers decision structures to low-end modalities without requiring low-end training images. K-MaT factorizes prompts, anchors them to clinical text descriptions, and aligns the low-end prompt manifold to the visually-grounded high-end space using Fused Gromov-Wasserstein optimal transport. We evaluate K-MaT on four cross-modal benchmarks, including dermoscopy, mammography to ultrasound, and CT to chest X-ray. K-MaT achieves state-of-the-art results, improving the average harmonic mean of accuracy to 44.1% (from BiomedCoOp's 42.0%) and macro-F1 to 36.2%. Notably, on the challenging breast imaging task, it mitigates the catastrophic forgetting seen in standard methods like CoOp (which drops to 27.0% accuracy on the low-end), preserving robust performance across modalities. Aligning prompt manifolds via optimal transport provides a highly effective route for the zero-shot cross-modal deployment of medical VLMs. |
| title | K-MaT: Knowledge-Anchored Manifold Transport for Cross-Modal Prompt Learning in Medical Imaging |
| topic | Computer Vision and Pattern Recognition Artificial Intelligence |
| url | https://arxiv.org/abs/2603.06340 |