Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Format: | Preprint |
| Veröffentlicht: |
2026
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| Schlagworte: | |
| Online-Zugang: | https://arxiv.org/abs/2603.07196 |
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Inhaltsangabe:
- Classical molecular dynamics and electro-diffusion theories have achieved profound success in elucidating ion selectivity and gating mechanisms. However, reconciling strict selectivity with high flux permeation in Angstrom-scaled biological ion channels poses a universal challenge in nanoscale physics, as classical models consistently underestimate single-channel conductance. Using a non perturbative quantum transport framework, we calculate the ion permeation dynamics through the selectivity filter within a transfer matrix formalism. We demonstrate that quantum tunneling allows ions to bypass classical Arrhenius suppression, quantitatively recovering the experimental conductance of Na+ and K+ channels. Crucially, our findings reveal that the exploitation of quantum mechanics is a fundamental prerequisite for achieving macroscopic physiological efficiency. By reframing ion channels as mesoscopic quantum conductors, this work establishes a transformative paradigm in quantum biology and predicts distinct transport resonances in the terahertz regime.