Miniaturized microscopes to study neural dynamics in freely-behaving animals
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arXiv
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| Auteurs principaux: | , |
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| Format: | Preprint |
| Publié: |
2026
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| _version_ | 1866915856466837504 |
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| author | Zong, Weijian Yang, Weijian |
| author_facet | Zong, Weijian Yang, Weijian |
| contents | Head-mounted miniaturized microscopes, commonly known as miniscopes, have undergone rapid development and seen widespread adoption over the past two decades, enabling the imaging of neural activity in freely-behaving animals such as rodents, songbirds, and non-human primates. These miniscopes facilitate numerous studies that are not feasible with head-fixed preparations. Recent advancements have enhanced their capabilities, allowing for faster imaging, larger fields of view, and deeper brain penetration. In this review, we examine the latest progress in one-photon and multi-photon miniscopes. We highlight the unique opportunities these devices present for neuroscience research, discuss the current technical challenges, and explore emerging technologies that promise to advance the development of miniscopes. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_11435 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | Miniaturized microscopes to study neural dynamics in freely-behaving animals Zong, Weijian Yang, Weijian Neurons and Cognition Optics Head-mounted miniaturized microscopes, commonly known as miniscopes, have undergone rapid development and seen widespread adoption over the past two decades, enabling the imaging of neural activity in freely-behaving animals such as rodents, songbirds, and non-human primates. These miniscopes facilitate numerous studies that are not feasible with head-fixed preparations. Recent advancements have enhanced their capabilities, allowing for faster imaging, larger fields of view, and deeper brain penetration. In this review, we examine the latest progress in one-photon and multi-photon miniscopes. We highlight the unique opportunities these devices present for neuroscience research, discuss the current technical challenges, and explore emerging technologies that promise to advance the development of miniscopes. |
| title | Miniaturized microscopes to study neural dynamics in freely-behaving animals |
| topic | Neurons and Cognition Optics |
| url | https://arxiv.org/abs/2603.11435 |