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| Main Authors: | , , , , , , , , |
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| Format: | Preprint |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2603.12010 |
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| _version_ | 1866914392399937536 |
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| author | Vogel, Patrick Kampf, Thomas Rückert, Martin A. Günther, Johanna Reichl, Teresa Bley, Thorsten A. Behr, Volker C. Gruschwitz, Philipp Hartung, Viktor |
| author_facet | Vogel, Patrick Kampf, Thomas Rückert, Martin A. Günther, Johanna Reichl, Teresa Bley, Thorsten A. Behr, Volker C. Gruschwitz, Philipp Hartung, Viktor |
| contents | Magnetic particle imaging (MPI) is a tracer-based technique that directly detects the distribution of magnetic iron-oxide nanoparticles with millisecond temporal resolution and no tissue background. Despite extensive preclinical work, in-vivo application of MPI in humans has not previously been reported. Here, we report the first in-vivo human MPI angiography, visualizing venous perfusion of the upper extremity using a human-scale scanner and clinically approved ferucarbotran. Under identical procedural conditions, we performed X-ray digital subtraction angiography as the clinical gold standard. MPI visualized major superficial and deep veins, including inflow, branching, valve filling, and clearance dynamics in real time with 2 frames per second. These results establish magnetic particle imaging as a clinically translatable modality for radiation-free vascular imaging in humans and mark the transition of MPI from preclinical research to first clinical application. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2603_12010 |
| institution | arXiv |
| publishDate | 2026 |
| record_format | arxiv |
| spellingShingle | First in-vivo human magnetic particle imaging Vogel, Patrick Kampf, Thomas Rückert, Martin A. Günther, Johanna Reichl, Teresa Bley, Thorsten A. Behr, Volker C. Gruschwitz, Philipp Hartung, Viktor Medical Physics Magnetic particle imaging (MPI) is a tracer-based technique that directly detects the distribution of magnetic iron-oxide nanoparticles with millisecond temporal resolution and no tissue background. Despite extensive preclinical work, in-vivo application of MPI in humans has not previously been reported. Here, we report the first in-vivo human MPI angiography, visualizing venous perfusion of the upper extremity using a human-scale scanner and clinically approved ferucarbotran. Under identical procedural conditions, we performed X-ray digital subtraction angiography as the clinical gold standard. MPI visualized major superficial and deep veins, including inflow, branching, valve filling, and clearance dynamics in real time with 2 frames per second. These results establish magnetic particle imaging as a clinically translatable modality for radiation-free vascular imaging in humans and mark the transition of MPI from preclinical research to first clinical application. |
| title | First in-vivo human magnetic particle imaging |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2603.12010 |