Halfway to 3D: Ensembling 2.5D and 3D Models for Robust COVID-19 CT Diagnosis

Fuente: arXiv
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Autori principali: Yang, Tuan-Anh, Bui, Bao V. Q., Vo-Van, Chanh-Quang, Hy, Truong-Son
Natura: Preprint
Pubblicazione: 2026
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author Yang, Tuan-Anh
Bui, Bao V. Q.
Vo-Van, Chanh-Quang
Hy, Truong-Son
author_facet Yang, Tuan-Anh
Bui, Bao V. Q.
Vo-Van, Chanh-Quang
Hy, Truong-Son
contents We propose a deep learning framework for COVID-19 detection and disease classification from chest CT scans that integrates both 2.5D and 3D representations to capture complementary slice-level and volumetric information. The 2.5D branch processes multi-view CT slices (axial, coronal, sagittal) using a DINOv3 vision transformer to extract robust visual features, while the 3D branch employs a ResNet-18 architecture to model volumetric context and is pretrained with Variance Risk Extrapolation (VREx) followed by supervised contrastive learning to improve cross-source robustness. Predictions from both branches are combined through logit-level ensemble inference. Experiments on the PHAROS-AIF-MIH benchmark demonstrate the effectiveness of the proposed approach: for binary COVID-19 detection, the ensemble achieves 94.48% accuracy and a 0.9426 Macro F1-score, outperforming both individual models, while for multi-class disease classification the 2.5D DINOv3 model achieves the best performance with 79.35% accuracy and a 0.7497 Macro F1-score. These results highlight the benefit of combining pretrained slice-based representations with volumetric modeling for robust multi-source medical imaging analysis. Code is available at https://github.com/HySonLab/PHAROS-AIF-MIH
format Preprint
id arxiv_https___arxiv_org_abs_2603_14832
institution arXiv
publishDate 2026
record_format arxiv
spellingShingle Halfway to 3D: Ensembling 2.5D and 3D Models for Robust COVID-19 CT Diagnosis
Yang, Tuan-Anh
Bui, Bao V. Q.
Vo-Van, Chanh-Quang
Hy, Truong-Son
Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
We propose a deep learning framework for COVID-19 detection and disease classification from chest CT scans that integrates both 2.5D and 3D representations to capture complementary slice-level and volumetric information. The 2.5D branch processes multi-view CT slices (axial, coronal, sagittal) using a DINOv3 vision transformer to extract robust visual features, while the 3D branch employs a ResNet-18 architecture to model volumetric context and is pretrained with Variance Risk Extrapolation (VREx) followed by supervised contrastive learning to improve cross-source robustness. Predictions from both branches are combined through logit-level ensemble inference. Experiments on the PHAROS-AIF-MIH benchmark demonstrate the effectiveness of the proposed approach: for binary COVID-19 detection, the ensemble achieves 94.48% accuracy and a 0.9426 Macro F1-score, outperforming both individual models, while for multi-class disease classification the 2.5D DINOv3 model achieves the best performance with 79.35% accuracy and a 0.7497 Macro F1-score. These results highlight the benefit of combining pretrained slice-based representations with volumetric modeling for robust multi-source medical imaging analysis. Code is available at https://github.com/HySonLab/PHAROS-AIF-MIH
title Halfway to 3D: Ensembling 2.5D and 3D Models for Robust COVID-19 CT Diagnosis
topic Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2603.14832